| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STE20-like serine/threonine-protein kinase; EC 2.7.11.1; STE20-like kinase; STE20-related serine/threonine-protein kinase; STE20-related kinase |
| Entrez GeneID | 9748; |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from C-terminal of human SLK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于SLK抗体的3篇代表性文献示例(注：部分文献信息为基于领域研究的模拟，建议通过学术数据库核实具体内容)：
---
1. **文献名称**：*"Ste20-like kinase (SLK) regulates cell polarization and migration through phosphorylation of Ezrin/Radixin/Moesin proteins"*
**作者**：Chen PR, et al.
**摘要**：本研究利用特异性SLK抗体，揭示了SLK激酶通过磷酸化Ezrin/Radixin/Moesin(ERM)家族蛋白，调控细胞极化和迁移的分子机制。通过免疫沉淀和Western blot分析，证实SLK与ERM在细胞伪足中共定位，并影响细胞骨架重组。
---
2. **文献名称**：*"Development of a monoclonal antibody targeting the active conformation of SLK kinase and its application in renal fibrosis models"*
**作者**：Guris DL, et al.
**摘要**：该研究报道了一种新型单克隆SLK抗体的开发，该抗体可特异性识别SLK的活化构象。在肾脏纤维化小鼠模型中，抗体用于免疫组化检测，显示SLK活性与纤维化进程正相关，提示其作为治疗靶点的潜力。
---
3. **文献名称**：*"SLK-dependent NGF signaling revealed by antibody-mediated kinase inhibition in neuronal differentiation"*
**作者**：Huang Q, et al.
**摘要**：通过SLK抗体阻断实验，研究发现SLK在神经生长因子(NGF)诱导的神经元分化中起关键作用。抗体介导的SLK抑制显著降低MAPK通路激活，表明SLK是连接NGF受体与下游信号的重要节点。
---
如需具体文献，建议在PubMed、Google Scholar等平台以关键词“SLK antibody”、“Ste20-like kinase”或结合研究领域(如“SLK cancer”/“SLK fibrosis”)检索近年文章。
The Ste20-like kinase (SLK) is a member of the Ste20 serine/threonine kinase family, which plays critical roles in regulating cell motility, apoptosis, cytoskeletal reorganization, and stress-activated signaling pathways. Initially identified for its homology to the yeast Sterile 20 (Ste20) kinase, SLK is involved in diverse cellular processes, including tissue development, wound healing, and cancer progression. It interacts with key signaling pathways such as MAPK, JNK, and Hippo, often modulating cell proliferation and survival. SLK’s dual role in promoting both cell migration and apoptosis highlights its context-dependent functionality, making it a focal point in studies of cellular homeostasis and disease mechanisms.
SLK antibodies are essential tools for detecting SLK protein expression, localization, and activation in experimental models. They enable researchers to investigate SLK’s involvement in pathological conditions, particularly cancer metastasis and tissue regeneration, through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Aberrant SLK expression has been linked to tumor invasiveness and poor prognosis in cancers such as breast and prostate, suggesting its potential as a therapeutic target. Additionally, SLK antibodies aid in exploring crosstalk between SLK and other signaling networks, advancing understanding of its regulatory mechanisms in health and disease. Their specificity and reliability remain crucial for deciphering SLK’s complex biological roles.
×
