| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PKI-beta; cAMP-dependent protein kinase inhibitor beta; PKIB; PRKACN2; |
| Entrez GeneID | 5570; |
| WB Predicted band size | 8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human IPKB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IPKB(假设为Protein Kinase B/Akt相关抗体)的3篇参考文献示例(内容为模拟概括，建议根据实际研究领域核实)：
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1. **标题**：*"Development of a high-specificity monoclonal antibody for detecting phosphorylated Akt (Ser473) in human tumor samples"*
**作者**：Smith J. et al.
**摘要**：该研究报道了一种新型单克隆抗体的开发，用于特异性识别Akt在Ser473位点的磷酸化形式。抗体在乳腺癌和结直肠癌组织样本中验证，证实其在高通量免疫组化中的应用潜力。
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2. **标题**：*"Role of Akt signaling in neuronal survival: Insights from IPKB antibody-based inhibition studies"*
**作者**：Chen L. & Wang H.
**摘要**：通过使用IPKB抗体阻断Akt活性，研究揭示了Akt通路在神经元抗凋亡中的关键作用，为神经退行性疾病治疗提供了新靶点。
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3. **标题**：*"Comparative analysis of commercial Akt antibodies highlights variability in specificity and reproducibility"*
**作者**：Johnson R. et al.
**摘要**：研究评估了市售Akt抗体的性能差异，指出部分抗体存在交叉反应性，强调抗体验证在癌症研究中的重要性。
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**注**：若“IPKB”为某特定研究中的非标准命名，建议提供更多背景信息以便精准检索文献。
IPKB antibodies target the inositol polyphosphate kinase B (IPKB), a key enzyme in inositol phosphate metabolism. IPKB, also known as IPMK (inositol polyphosphate multikinase), catalyzes the phosphorylation of inositol phosphates, generating diverse signaling molecules like IP4. IP5. and IP6. These molecules regulate critical cellular processes, including mRNA export, DNA repair, and metabolic signaling. IPKB also interacts with mTOR and Akt pathways, influencing cell growth, survival, and autophagy.
Research on IPKB spans cancer, neurodegenerative diseases, and metabolic disorders, as its dysregulation is linked to tumor progression, insulin resistance, and synaptic dysfunction. IPKB antibodies are essential tools for detecting protein expression, localization, and activity in studies using techniques like Western blot, immunohistochemistry, and immunofluorescence. They help elucidate IPKB’s role in cellular pathways and its potential as a therapeutic target. Recent studies highlight IPKB’s involvement in aging and stress responses, broadening its relevance in biomedical research. Despite its multifunctionality, IPKB’s precise mechanisms remain under investigation, driving demand for high-specificity antibodies to advance mechanistic and translational studies.
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