首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal RHBT2 Antibody

  • 中文名： RHBT2抗体
  • 别    名： Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein;
货号: IPDX42101
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/3000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein;
Entrez GeneID23221;
WB Predicted band size83kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human RHBT2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是3篇可能与RHBT2抗体相关的文献示例(注：RHBT2相关研究较少，以下为模拟内容供参考)：

1. **文献名称**：*RHBT2 regulates ammonium transport in renal tubular cells*

**作者**：Smith A, et al.

**摘要**：研究揭示了RHBT2蛋白在肾脏铵离子转运中的关键作用，并开发了一种特异性RHBT2抗体，证实其在酸碱平衡调节中的分子机制。

2. **文献名称**：*Expression and functional analysis of RHBT2 in breast cancer progression*

**作者**：Chen L, et al.

**摘要**：通过RHBT2抗体免疫组化分析，发现RHBT2在乳腺癌组织中的高表达与肿瘤侵袭性相关，提示其可能作为潜在治疗靶点。

3. **文献名称**：*RHBT2 antibody-based screening identifies novel biomarkers in hepatocellular carcinoma*

**作者**：Wang Y, et al.

**摘要**：利用RHBT2抗体进行蛋白质组学筛选，鉴定出肝癌细胞中与RHBT2互作的信号通路蛋白，为肝癌诊断提供新思路。

**备注**：

RHBT2(Rh Family B Transporter 2)相关研究较少，实际文献可能需要通过更精确的关键词(如基因名**SLC42A2**)或功能(铵转运蛋白)检索。建议查阅**NCBI PubMed**或**UniProt数据库**获取最新信息。

背景信息

The RHBDD2 antibody targets the Rhomboid domain-containing protein 2 (RHBDD2), a member of the rhomboid protease family implicated in regulating intracellular proteolytic processes. RHBDD2 is an intramembrane serine protease that modulates protein cleavage and signaling pathways, particularly those involving endoplasmic reticulum (ER)-associated degradation (ERAD) and apoptosis. Initially identified through genomic studies, RHBDD2 has been linked to cancer progression, with overexpression observed in certain malignancies, where it may promote tumor cell survival by suppressing ER stress-induced apoptosis. Research suggests its role in cleaving substrates like BIK, a pro-apoptotic protein, thereby influencing cell fate. The RHBDD2 antibody serves as a critical tool for detecting RHBDD2 expression in tissues or cell lines, aiding studies on its biological functions and mechanisms. Recent investigations explore its potential as a therapeutic target, given its association with chemoresistance and metastasis. However, detailed structural and functional insights into RHBDD2 remain limited, necessitating further exploration of its substrate specificity and regulatory networks. Commercial RHBDD2 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, though specificity challenges due to sequence homology within the rhomboid family require careful experimental controls.

客户数据及评论

折叠内容

大包装询价

×