Rabbit Polyclonal RHBT2 Antibody

The RHBDD2 antibody targets the Rhomboid domain-containing protein 2 (RHBDD2), a member of the rhomboid protease family implicated in regulating intracellular proteolytic processes. RHBDD2 is an intramembrane serine protease that modulates protein cleavage and signaling pathways, particularly those involving endoplasmic reticulum (ER)-associated degradation (ERAD) and apoptosis. Initially identified through genomic studies, RHBDD2 has been linked to cancer progression, with overexpression observed in certain malignancies, where it may promote tumor cell survival by suppressing ER stress-induced apoptosis. Research suggests its role in cleaving substrates like BIK, a pro-apoptotic protein, thereby influencing cell fate. The RHBDD2 antibody serves as a critical tool for detecting RHBDD2 expression in tissues or cell lines, aiding studies on its biological functions and mechanisms. Recent investigations explore its potential as a therapeutic target, given its association with chemoresistance and metastasis. However, detailed structural and functional insights into RHBDD2 remain limited, necessitating further exploration of its substrate specificity and regulatory networks. Commercial RHBDD2 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, though specificity challenges due to sequence homology within the rhomboid family require careful experimental controls.