| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ZNF668; Zinc finger protein 668; |
| Entrez GeneID | 79759; |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human ZNF668. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF668抗体的3篇文献示例(注：文献信息为模拟，实际文献需通过学术数据库验证)：
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1. **文献名称**：*ZNF668 interacts with p53 to regulate DNA damage response in breast cancer*
**作者**：Li X, Wang Y, Chen J
**摘要**：本研究通过免疫共沉淀和Western blot技术，利用ZNF668抗体验证了ZNF668与p53的物理相互作用，揭示了其在乳腺癌细胞DNA损伤修复中的调控机制，表明ZNF668缺失可能促进基因组不稳定性。
2. **文献名称**：*Epigenetic silencing of ZNF668 contributes to hepatocellular carcinoma progression*
**作者**：Zhang H, Liu R, Guo F
**摘要**：通过免疫组化(使用ZNF668特异性抗体)和甲基化分析，发现ZNF668在肝癌组织中表达下调，其缺失与患者预后不良相关，提示ZNF668可能作为肿瘤抑制因子通过调控Wnt/β-catenin通路发挥作用。
3. **文献名称**：*Development and validation of a novel ZNF668 monoclonal antibody for functional studies*
**作者**：Kim S, Park M, Lee DH
**摘要**：本文报道了一种高特异性ZNF668单克隆抗体的开发，验证了其在流式细胞术、免疫荧光和ChIP-seq中的应用，并证明ZNF668在细胞周期调控中的新功能。
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**提示**：建议通过PubMed或Google Scholar以“ZNF668 antibody”或“ZNF668 function”为关键词检索最新文献，或查阅涉及锌指蛋白家族在癌症或表观遗传调控中的研究。
The ZNF668 antibody is a research tool designed to detect and study Zinc Finger Protein 668 (ZNF668), a member of the zinc finger-containing transcription factor family. ZNF668 is implicated in transcriptional regulation, DNA damage response, and tumor suppression. It contains multiple C2H2-type zinc finger domains, which enable interactions with DNA or other proteins to modulate gene expression. Studies suggest ZNF668 acts as a tumor suppressor by stabilizing p53. inhibiting oncogenic pathways like MDM2-mediated p53 degradation, and maintaining genomic stability. Dysregulation of ZNF668 has been linked to cancers, including breast, liver, and colorectal cancer.
The ZNF668 antibody is typically produced in immunized hosts (e.g., rabbits or mice) using peptide antigens derived from specific regions of the ZNF668 protein. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interaction partners in cell lines or tissue samples. Researchers employ this antibody to explore ZNF668's role in cellular stress responses, tumorigenesis, and therapeutic resistance. Its specificity and reliability are validated through knockdown/knockout controls or epitope mapping. As a critical reagent, the ZNF668 antibody aids in elucidating molecular mechanisms underlying cancer progression and potential targets for therapy.
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