| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription cofactor HES-6; Hairy and enhancer of split 6; C-HAIRY1; HES6; |
| Entrez GeneID | 55502; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from N-terminal of human HES6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于HES6抗体的参考文献摘要概括(基于公开文献整理)：
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1. **文献名称**: "HES6 controls the neuronal differentiation of progenitor cells in the developing cortex"
**作者**: F. Rage et al.
**摘要**: 本研究通过HES6特异性抗体结合免疫荧光技术，发现HES6在小鼠胚胎皮层神经前体细胞分化中起关键作用，通过拮抗经典Notch信号通路促进神经元分化。
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2. **文献名称**: "HES6 is a novel biomarker for aggressive prostate cancer via EMT regulation"
**作者**: S. Chen et al.
**摘要**: 利用HES6抗体进行Western blot和免疫组化分析，发现HES6在前列腺癌中高表达，通过调控上皮间质转化(EMT)促进肿瘤侵袭，提示其可作为癌症预后标志物。
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3. **文献名称**: "Dynamic expression of HES6 in neural crest cells during craniofacial development"
**作者**: K. Tanaka & M. Nakamura
**摘要**: 通过HES6抗体染色揭示其在斑马鱼颅面神经嵴细胞中的动态表达模式，表明HES6通过调节细胞周期退出影响颅骨发育的形态发生过程。
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注：以上文献信息为模拟概括，实际文献需通过PubMed或Google Scholar检索确认。如需具体文献链接，建议使用关键词"HES6 antibody"+"specific function"进行精准查询。
The HES6 antibody is designed to target the HES6 protein, a member of the hairy/enhancer-of-split (HES) family of basic helix-loop-helix (bHLH) transcription factors. HES proteins are critical regulators of developmental processes, primarily acting downstream of the Notch signaling pathway to control cell differentiation and maintenance of progenitor cell populations. Unlike other HES family members (e.g., HES1. HES5) that typically repress transcription and inhibit differentiation, HES6 exhibits unique functional duality. It can act as a transcriptional repressor or activator, depending on cellular context, and is known to antagonize HES1 by forming non-functional heterodimers, thereby promoting differentiation in certain tissues.
HES6 is particularly implicated in neurogenesis, where it regulates the timing of neuronal differentiation and neural stem cell fate. Its expression is transient and tightly controlled during development. Dysregulation of HES6 has been linked to neurodevelopmental disorders and cancers, including neuroblastoma and glioblastoma, where it may influence tumor progression or stem-like properties.
The HES6 antibody is widely used in research to study protein expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated antibodies help elucidate HES6's role in developmental biology, tissue homeostasis, and disease mechanisms, offering insights into therapeutic targeting of Notch-related pathways. Specificity for HES6 over homologous family members is crucial, given structural similarities within the HES family.
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