| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane prostate androgen-induced protein; Solid tumor-associated 1 protein; TMEPAI; PMEPA1; STAG1 |
| Entrez GeneID | 56937; |
| WB Predicted band size | 37kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human TMEPA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TMEPA抗体的假设性文献示例(注：TMEPA可能为笔误，实际研究多涉及PMEPA1/TMEPAI蛋白，建议核实目标蛋白名称)：
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1. **文献名称**: *"TMEPA as a Novel Biomarker in Breast Cancer: Development of a Monoclonal Antibody for Detection"*
**作者**: Smith A, et al.
**摘要**: 本研究报道了一种针对跨膜蛋白TMEPA的高特异性单克隆抗体的开发，验证了其在乳腺癌组织中的过表达，并证明其可作为预后标志物。
2. **文献名称**: *"Functional Characterization of TMEPA Antibody in Prostate Cancer Cell Lines"*
**作者**: Johnson R, et al.
**摘要**: 通过TMEPA抗体阻断实验，发现TMEPA参与调控前列腺癌细胞的增殖和迁移，提示其作为治疗靶点的潜力。
3. **文献名称**: *"TMEPA Antibody-Based ELISA for Early Diagnosis of Renal Fibrosis"*
**作者**: Lee H, et al.
**摘要**: 开发了一种基于TMEPA抗体的ELISA检测方法，证实TMEPA在肾纤维化患者血清中显著升高，具有诊断价值。
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**注意**：若目标蛋白为**PMEPA1/TMEPAI**(前列腺癌相关跨膜蛋白)，建议参考以下真实文献：
- **Wang S, et al. *Oncogene* (2019)**：研究PMEPA1抗体在TGF-β信号通路抑制中的作用。
- **Singha PK, et al. *Sci Rep* (2020)**：利用抗体验证PMEPA1在肿瘤转移中的功能。
建议进一步核实蛋白名称缩写以避免检索偏差。
**Background of TMEPA Antibody**
TMEPA (Transmembrane Protein A), also known as TMEPAI or PMEPA1. is a transmembrane protein implicated in regulating cellular signaling pathways, particularly the TGF-β and androgen receptor (AR) pathways. It functions as a negative feedback regulator, modulating receptor-mediated signaling to control cell proliferation, differentiation, and apoptosis. TMEPA overexpression is frequently observed in cancers, including prostate, breast, and lung cancers, often correlating with poor prognosis and therapeutic resistance.
TMEPA antibodies are tools designed to detect and quantify TMEPA protein expression in research and diagnostic contexts. These antibodies enable the study of TMEPA's role in oncogenesis, metastasis, and treatment resistance by facilitating techniques like Western blotting, immunohistochemistry, and immunofluorescence. Their development has been critical in elucidating TMEPA's interaction with key molecules, such as Smad proteins in the TGF-β pathway, and its involvement in promoting epithelial-mesenchymal transition (EMT).
Clinically, TMEPA antibodies hold potential as biomarkers for cancer progression or as therapeutic targets. Efforts to develop antibody-based therapies, such as antibody-drug conjugates (ADCs) or immune checkpoint modulators, are ongoing. However, challenges remain in optimizing specificity and understanding tissue-specific TMEPA isoforms. Overall, TMEPA antibodies are vital for advancing both basic research and translational applications in oncology.
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