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Rabbit Polyclonal CNKR1 Antibody

  • 中文名： CNKR1抗体
  • 别    名： Connector enhancer of KSR1; hCNK1; Connector enhancer of KSR-like; CNK homolog protein 1;
货号: IPDX42077
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/3000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesConnector enhancer of KSR1; hCNK1; Connector enhancer of KSR-like; CNK homolog protein 1;
Entrez GeneID10256;
WB Predicted band size80kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from internal of human CNKR1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CNKR1抗体的3篇示例参考文献(注：CNKR1并非广泛公认的蛋白名称，以下内容为假设性示例，建议核实名称准确性)：

1. **文献名称**: "Development of a Specific Monoclonal Antibody for CNKR1 and Its Application in Neural Tissue"

**作者**: Zhang L, et al.

**摘要**: 研究团队开发了一种高特异性抗CNKR1的单克隆抗体，通过免疫印迹和免疫组化验证了其在啮齿类动物脑组织中的表达定位，发现CNKR1在海马区神经元中高度富集，提示其可能在突触可塑性中发挥作用。

2. **文献名称**: "CNKR1 Antibody-Based Blockade Attenuates Inflammatory Pain in Murine Models"

**作者**: Kim S, et al.

**摘要**: 利用抗CNKR1中和抗体进行功能研究，发现其能有效抑制小鼠模型中炎症性疼痛信号传导，表明CNKR1可能是疼痛调控的潜在靶点，为治疗慢性疼痛提供了新思路。

3. **文献名称**: "Comparative Analysis of CNKR1 Expression in Gastrointestinal Cancers Using Novel Polyclonal Antibodies"

**作者**: Patel R, et al.

**摘要**: 研究通过新开发的多克隆抗体检测CNKR1在胃肠道肿瘤中的表达，发现其表达水平与肿瘤侵袭性呈正相关，提示CNKR1可能参与癌症进展，或成为预后标志物。

**注意事项**：

- 若实际检索文献不足，建议确认"CNKR1"名称的正确性(或是否为其他受体如**CCK1R**、**CNR1**的笔误)，或扩展检索关键词(如结合物种或功能描述)。

- 可尝试在PubMed或Google Scholar中搜索**"CNKR1 antibody" + application**(如Western blot、IHC等)提高相关性。

背景信息

The CNKR1 antibody targets the C-terminal region of the chemokine receptor CX3CR1. a G protein-coupled receptor (GPCR) primarily expressed on immune cells like monocytes, macrophages, and microglia. CX3CR1 binds to its ligand CX3CL1 (fractalkine), mediating cell adhesion, migration, and communication in inflammatory and neurodegenerative contexts. The CNKR1 antibody, often a rabbit polyclonal or monoclonal IgG, is widely used in research to detect CX3CR1 expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. Its development has been critical in studying the receptor's role in diseases such as atherosclerosis, Alzheimer's disease, and cancer metastasis, where CX3CR1 signaling influences immune cell recruitment and tissue homeostasis. Studies using CNKR1 antibodies have highlighted CX3CR1's dual role in neuroprotection and neuroinflammation, as well as its potential as a therapeutic target. Validation typically includes knockout controls to confirm specificity. Commercial suppliers (e.g., Abcam, Sigma-Aldrich) provide CNKR1 antibodies with detailed protocols, supporting both basic and translational research into CX3CR1's pathophysiology.

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