Rabbit Polyclonal RIN3 Antibody

RIN3 (Ras and Rab interactor 3) is a multifunctional protein involved in intracellular signaling and membrane trafficking, primarily acting as a guanine nucleotide exchange factor (GEF) for Rab5 and Rab31 GTPases. It plays a critical role in regulating endosomal trafficking, receptor internalization, and cytoskeletal dynamics. Dysregulation of RIN3 has been implicated in pathologies such as cancer, Alzheimer’s disease, and osteoporosis, highlighting its importance in cellular homeostasis. Antibodies targeting RIN3 are essential tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect RIN3 in various tissues and cell lines. Given RIN3's interaction with signaling pathways linked to cell proliferation and vesicle transport, its study provides insights into mechanisms underlying tumor progression, neurodegenerative disorders, and bone metabolism. Commercial RIN3 antibodies are typically validated for specificity against conserved epitopes, though variability may exist due to alternative splicing isoforms. Research utilizing these antibodies has helped clarify RIN3's role in modulating EGFR trafficking, amyloid precursor protein processing, and osteoclast activity, making it a potential therapeutic target. Ongoing studies continue to explore its broader biological significance and disease associations.