Rabbit Polyclonal ADCK3 Antibody

The ADCK3 (AarF Domain Containing Kinase 3) antibody is a tool used to study the protein encoded by the ADCK3 gene, also known as COQ8A or CABC1. ADCK3 is a mitochondrial kinase involved in the biosynthesis of coenzyme Q10 (CoQ10), a vital component of the electron transport chain and cellular antioxidant defense. It regulates CoQ10 synthesis by stabilizing the multi-protein complex required for its production. Mutations in ADCK3 are linked to primary CoQ10 deficiency, a rare mitochondrial disorder characterized by cerebellar ataxia, encephalopathy, and myopathy. Research using ADCK3 antibodies focuses on understanding its role in mitochondrial energy metabolism, oxidative stress, and neurodegenerative diseases like Parkinson’s. These antibodies are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect ADCK3 expression, localization, and interaction partners in cellular or tissue samples. Studies also explore ADCK3's potential as a therapeutic target, particularly in diseases associated with CoQ10 dysfunction. By enabling precise detection of ADCK3. these antibodies contribute to unraveling molecular mechanisms in mitochondrial pathologies and advancing biomarker discovery or treatment strategies.