Rabbit Polyclonal IPMK Antibody

IPMK (Inositol Polyphosphate Multikinase) is an evolutionarily conserved enzyme that phosphorylates inositol polyphosphates (e.g., IP3. IP4) and plays a critical role in cellular signaling, metabolic regulation, and chromatin remodeling. It generates higher-order inositol phosphates like IP4. IP5. and IP6. which regulate processes such as mRNA export, DNA repair, and Akt signaling. IPMK also exhibits non-catalytic functions, including acting as a transcriptional coactivator for p53 and other transcription factors. IPMK antibodies are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies, typically developed in rabbits or mice, enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers use them to explore IPMK's roles in cancer, metabolic disorders, and neurodegenerative diseases, where its dysregulation has been implicated. Validation often involves knockout cell lines to confirm specificity. Due to IPMK's dual enzymatic and scaffolding functions, its antibodies help dissect complex signaling networks, aiding drug discovery and mechanistic studies. Commercial IPMK antibodies are available, but rigorous validation remains crucial given potential cross-reactivity with related kinases.