Rabbit Polyclonal PPHLN Antibody

The PPHLN antibody targets the protein Periphilin (PPHLN), a component of the epidermal differentiation complex (EDC) crucial for skin barrier formation. Initially identified as a peripheral protein in the cornified envelope, PPHLN is involved in terminal keratinocyte differentiation, interacting with proteins like filaggrin and loricrin to maintain epithelial integrity. Beyond dermatology, PPHLN has roles in chromatin organization through its association with heterochromatin protein 1 (HP1), influencing gene silencing and genomic stability. Dysregulation of PPHLN is linked to skin disorders (e.g., psoriasis, atopic dermatitis) and cancer, where its aberrant expression correlates with tumor progression and metastasis. The PPHLN antibody serves as a vital tool in studying these mechanisms, enabling detection of protein localization, expression levels, and molecular interactions in both physiological and pathological contexts. Its applications span basic research on epithelial biology, cancer biomarker discovery, and therapeutic target validation. Recent studies also explore PPHLN's role in RNA metabolism and stress granule formation, expanding its relevance to cellular stress responses. Despite progress, functional nuances of PPHLN isoforms and tissue-specific roles remain under investigation, highlighting the antibody's continued importance in elucidating this multifaceted protein's biology.