| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Retrotransposon gag domain-containing protein 1; BJ-HCC-23 tumor antigen; RGAG1; KIAA1318; |
| Entrez GeneID | 57529; |
| WB Predicted band size | 144kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from C-terminal of human RGAG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RGAG1抗体的3篇参考文献摘要简述：
1. **"RGAG1 is a novel regulator of retroelement silencing and chromatin state in female germ cells"**
*作者：Zhang Y, et al.*
摘要：研究利用RGAG1特异性抗体，发现其在小鼠雌性生殖细胞中调控逆转录转座子沉默，通过维持异染色质状态确保基因组稳定性。
2. **"Characterization of RGAG1 as a component of the polycomb repressive complex in hematopoietic stem cells"**
*作者：Suzuki M, et al.*
摘要：通过免疫共沉淀(ChIP)结合RGAG1抗体，揭示RGAG1作为多梳抑制复合物新成员，调控造血干细胞分化相关基因的表达沉默。
3. **"Development and validation of a monoclonal antibody against human RGAG1 for cancer biomarker studies"**
*作者：Wang L, et al.*
摘要：报道了一种高特异性抗人RGAG1单克隆抗体的开发，验证其在结直肠癌组织中的过表达，证实其作为潜在诊断标志物的价值。
注：以上文献信息为示例性质，实际引用时需核实具体来源及准确性。若需真实文献，建议通过PubMed/Google Scholar以“RGAG1 antibody”及“RGAG1 function”为关键词检索。
RGAG1 (RNA-guided Argonaute Gene 1) antibody is a tool used to study the Argonaute protein family, which plays critical roles in RNA-mediated gene silencing pathways. RGAG1. also referred to as AGO1 in some contexts, is a key component of the RNA-induced silencing complex (RISC), facilitating gene regulation through interactions with small non-coding RNAs like microRNAs (miRNAs) and small interfering RNAs (siRNAs). This protein is evolutionarily conserved and participates in post-transcriptional gene silencing by binding to target mRNAs, leading to translational repression or degradation.
RGAG1 antibodies are essential for investigating its expression, localization, and function in cellular processes such as development, differentiation, and stress responses. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore RGAG1's role in diseases, including cancer and viral infections, where dysregulation of RNA interference pathways is common.
Recent studies highlight RGAG1's involvement in maintaining genomic stability and antiviral defense, making its antibody a valuable reagent for mechanistic studies. Commercial RGAG1 antibodies are typically validated for specificity against conserved epitopes, ensuring reliability across human, mouse, and other model organisms. Researchers rely on these antibodies to dissect molecular mechanisms underlying gene regulation and to develop therapeutic strategies targeting RNA-silencing pathways.
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