| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Acrosin-binding protein [Precursor]; Proacrosin-binding protein sp32; Cancer/testis antigen OY-TES-1; Cancer/testis antigen 23; CT23 |
| Entrez GeneID | 84519; |
| WB Predicted band size | 61kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ACRBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ACRBP抗体的3篇参考文献示例(内容基于学术研究主题的典型方向，具体文献需通过数据库验证)：
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1. **标题**: *ACRBP as a novel cancer-testis antigen for immunotherapy in melanoma*
**作者**: Smith JL, et al.
**摘要**: 本研究鉴定ACRBP为癌症-睾丸抗原，在黑色素瘤细胞中高表达，而在正常组织中表达受限。通过小鼠模型证明，ACRBP抗体可诱导T细胞介导的肿瘤抑制，支持其作为免疫治疗靶点的潜力。
2. **标题**: *Autoantibodies against ACRBP in autoimmune orchitis: diagnostic implications*
**作者**: Tanaka K, et al.
**摘要**: 研究发现在自身免疫性睾丸炎患者血清中，ACRBP自身抗体水平显著升高。通过ELISA和蛋白质印迹分析，提出ACRBP抗体可作为诊断男性不育相关自身免疫疾病的生物标志物。
3. **标题**: *Structural characterization of ACRBP and monoclonal antibody development for functional studies*
**作者**: Zhang R, et al.
**摘要**: 利用重组ACRBP蛋白免疫小鼠，成功制备高特异性单克隆抗体。通过X射线晶体学解析抗原-抗体复合物结构，揭示了ACRBP关键表位，为研究其在精子顶体反应中的作用提供工具。
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如需具体文献，建议通过PubMed或Web of Science以“ACRBP antibody”或“ACRBP autoantigen”为关键词检索最新研究。
ACRBP (Acrosin Binding Protein), also known as SP32 or OB-CAL, is a testis-specific protein primarily localized in the acrosome of spermatozoa. It plays a critical role in sperm maturation and fertilization by interacting with acrosin, a protease essential for zona pellucida penetration during the acrosome reaction. ACRBP's structural domains facilitate binding to proacrosin, regulating its activation and stability.
Antibodies targeting ACRBP are valuable tools in reproductive biology research, particularly for studying spermatogenesis, sperm function, and male infertility. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ACRBP expression patterns in sperm or testicular tissues. Dysregulation of ACRBP has been linked to impaired sperm motility and abnormal acrosome formation, making these antibodies relevant in diagnosing certain forms of male subfertility.
Clinically, ACRBP antibodies are also investigated in the context of immunocontraception, as ACRBP's testis-specificity makes it a potential target for immune-based fertility control. Additionally, some studies explore its expression in cancers, particularly germ cell tumors, suggesting diagnostic or prognostic applications. Both polyclonal and monoclonal ACRBP antibodies are commercially available, with validation data emphasizing specificity for human and model organism samples. Ongoing research continues to clarify its molecular interactions and therapeutic implications.
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