| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CK1; CK1-alpha2; CKI-alpha; CSNK1A1L; EC 2.7.11.1 |
| Entrez GeneID | 122011; |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CKI-α1/L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇与CKI-α1/L(Casein Kinase 1 alpha 1)抗体相关的参考文献示例，包含文献名称、作者及摘要内容概括：
---
1. **文献名称**: "Casein kinase 1α regulates Wnt signaling and β-catenin subcellular localization"
**作者**: Saito-Diaz K, et al.
**摘要**: 该研究利用CKI-α1/L抗体通过免疫荧光和Western blot技术，揭示了CK1α在Wnt信号通路中对β-catenin的磷酸化调控及其核质转运的影响，证明CK1α活性变化可改变β-catenin的亚细胞定位和下游靶基因表达。
---
2. **文献名称**: "Targeting casein kinase 1α in cancer: Mechanisms and therapeutic potential"
**作者**: Zhang Y, et al.
**摘要**: 研究者通过CKI-α1/L抗体检测多种癌细胞系中CK1α的表达水平，发现其在结直肠癌中显著上调。实验进一步表明，抑制CK1α可协同增强化疗药物敏感性，提示其作为癌症治疗靶点的潜力。
---
3. **文献名称**: "CKIα ablation leads to p53-dependent apoptosis via disrupted ribosome biogenesis"
**作者**: Masuda M, et al.
**摘要**: 研究通过CKI-α1/L抗体验证CK1α基因敲除后细胞中p53蛋白的稳定性变化，发现CK1α缺失导致核糖体生物合成异常，进而激活p53依赖性凋亡通路，为白血病治疗提供了新机制依据。
---
注：以上文献为示例性内容，实际引用时需核对真实论文信息。建议通过PubMed或Web of Science以“CK1α antibody”或“Casein Kinase 1 alpha 1”为关键词检索最新研究。
The casein kinase 1 alpha 1-like (CKI-α1/L) antibody is a tool used to detect the CKI-α1/L protein, a member of the casein kinase 1 (CK1) serine/threonine kinase family. CK1 enzymes regulate diverse cellular processes, including Wnt/β-catenin signaling, DNA repair, circadian rhythms, and cell cycle progression. CKI-α1/L, encoded by the *CSNK1A1L* gene, shares high homology with CKI-α (CSNK1A1) but differs in its N-terminal region due to alternative splicing. This structural variation may influence substrate specificity or subcellular localization, though its exact functional distinctions remain under investigation.
CKI-α1/L is implicated in disease pathways, particularly cancer. Dysregulation of CK1 isoforms is linked to tumorigenesis, as they modulate oncogenic signaling cascades like Wnt and Hedgehog. Antibodies targeting CKI-α1/L enable researchers to study its expression patterns, interaction partners, and roles in pathological contexts. For example, altered CKI-α1/L levels have been observed in certain malignancies, suggesting potential diagnostic or therapeutic relevance. Additionally, CKI-α1/L antibodies are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its tissue distribution and dynamic regulation under physiological or stress conditions. Ongoing research aims to clarify its unique contributions to CK1-mediated signaling networks and its utility as a biomarker or drug target.
×
