Rabbit Polyclonal KIAA1967 Antibody

The KIAA1967 antibody is a research tool designed to detect the protein encoded by the KIAA1967 gene, also known as DBC1 (Deleted in Breast Cancer 1) or CCAR2 (Cell Cycle and Apoptosis Regulator 2). This gene has garnered attention due to its potential roles in cellular processes such as DNA repair, apoptosis, and cell cycle regulation. Initially identified as a gene deleted in breast cancer, subsequent studies revealed its broader involvement in cancer biology, though its exact function remains debated—acting as either an oncogene or tumor suppressor depending on context. The KIAA1967 antibody is typically generated using recombinant protein fragments or synthetic peptides corresponding to specific epitopes within the protein, often produced in hosts like rabbits or mice. It has been widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study protein expression patterns, subcellular localization, and interactions with partners like SIRT1. p53. or estrogen receptor-alpha. Researchers utilize this antibody to explore KIAA1967's role in oxidative stress responses, epigenetic regulation, and therapeutic resistance in cancers, including breast, lung, and liver malignancies. Validation steps, such as knockout controls, are critical due to occasional cross-reactivity concerns. Ongoing studies aim to clarify its dual roles in tumorigenesis and potential as a biomarker or therapeutic target.