Rabbit Polyclonal ADCK1 Antibody

The ADCK1 (aarF domain-containing kinase 1) antibody is a research tool targeting the ADCK1 protein, a member of the ADCK family of atypical kinases. ADCK1 is a mitochondrial-associated protein implicated in coenzyme Q (CoQ) biosynthesis and cellular energy metabolism. Though less characterized than its paralog ADCK3. ADCK1 is believed to interact with components of the CoQ synthesis complex, potentially regulating CoQ levels critical for electron transport chain function. Studies suggest its involvement in mitochondrial homeostasis, oxidative stress response, and cell survival pathways. The ADCK1 antibody is widely used in Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, subcellular localization, and interactions in various tissues, particularly in models of mitochondrial dysfunction or metabolic disorders. Its development has facilitated investigations into ADCK1's role in diseases like neurodegenerative conditions, cardiomyopathies, and cancer, where mitochondrial dysregulation is a hallmark. However, functional insights remain limited due to overlapping roles with other ADCK family members and incomplete mechanistic understanding. Commercial ADCK1 antibodies are typically validated for specificity in human, mouse, or rat samples, though cross-reactivity varies. Ongoing research aims to clarify ADCK1's molecular functions and therapeutic potential, with its antibody serving as a critical reagent for exploratory studies in mitochondrial biology and disease mechanisms.