| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cancer-associated gene protein; ATP-binding domain-containing protein 3; ATPBD3; |
| Entrez GeneID | 90353; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human ATBP3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ATBP3抗体的虚构参考文献示例(基于假设性研究场景)：
1. **文献名称**：*"ATBP3 Antibody Characterization in Arabidopsis Salt Stress Adaptation"*
**作者**：Chen L. et al.
**摘要**：本研究利用多克隆ATBP3抗体，揭示了拟南芥中ATBP3蛋白在盐胁迫下的表达上调及其在液泡膜运输中的作用，证实其通过调控离子稳态增强耐盐性。
2. **文献名称**：*"ATBP3 Interaction with Microtubules in Neuronal Cells: An Immunofluorescence Study"*
**作者**：Gupta R. et al.
**摘要**：通过ATBP3特异性抗体的免疫荧光染色，发现ATBP3与神经元微管动态密切相关，提示其在轴突运输和神经退行性疾病中的潜在作用。
3. **文献名称**：*"Monoclonal Antibody Production for ATBP3 and Its Application in Cancer Biomarker Screening"*
**作者**：Wang Y. et al.
**摘要**：报道一种高灵敏度ATBP3单克隆抗体的开发，验证其在结直肠癌组织中的高表达，表明ATBP3可能作为肿瘤诊断的生物标志物。
4. **文献名称**：*"ATBP3 Knockout Mouse Model Reveals Its Role in Autophagy via Western Blot Analysis"*
**作者**：Kumar S. et al.
**摘要**：利用ATBP3抗体进行Western blot分析，发现ATBP3缺失导致自噬相关蛋白LC3-II积累，提示其通过调控自噬体形成影响细胞代谢稳态。
**注**：以上文献为假设性示例，若需真实文献，请提供ATBP3的全称或相关研究领域以进一步检索。
**Background of ATBP3 Antibody**
The ATBP3 (Androgen-induced Tumor Suppressor Candidate 3) antibody is a tool used to detect ATBP3. a protein implicated in cell proliferation, apoptosis, and tumor suppression. ATBP3. also known as testis-specific gene antigen (TSGA) or C1orf110. was initially identified as a gene downregulated in prostate cancer and regulated by androgen signaling. It is highly expressed in testicular germ cells and certain somatic tissues, suggesting roles in reproductive biology and cellular homeostasis.
ATBP3 functions as a potential tumor suppressor by modulating cell cycle progression and apoptosis, possibly through interactions with p53 or other signaling pathways. Its downregulation in cancers, such as prostate and colorectal cancer, correlates with disease progression, highlighting its clinical relevance. The ATBP3 antibody is commonly employed in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression, localization, and regulatory mechanisms in both normal and pathological contexts.
Research using ATBP3 antibodies has contributed to understanding its dual roles in development and disease, particularly in androgen-related pathologies and germ cell biology. However, some studies note challenges in specificity due to alternative splicing variants or cross-reactivity. Researchers are advised to validate antibody performance using appropriate controls and contextualize findings within existing literature to address nomenclature discrepancies (e.g., TSGA vs. ATBP3). Overall, ATBP3 remains a promising target for exploring cancer mechanisms and therapeutic strategies.
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