| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized aarF domain-containing protein kinase 2; EC 2.7.11.-; ADCK2; AARF; |
| Entrez GeneID | 90956; |
| WB Predicted band size | 69kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ADCK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADCK2抗体的模拟参考文献示例(基于常见研究主题的合理推测，非真实文献)：
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1. **"Development and validation of a specific ADCK2 polyclonal antibody for mitochondrial protein analysis"**
*Authors: Smith J, et al.*
**摘要**: 本研究开发了一种针对人ADCK2的多克隆抗体，并通过Western blot和免疫荧光验证其特异性。抗体成功用于检测多种细胞系中线粒体定位的ADCK2蛋白，为后续功能研究提供工具。
2. **"ADCK2 regulates cellular energy metabolism in hepatocellular carcinoma: Insights from antibody-based profiling"**
*Authors: Zhang L, et al.*
**摘要**: 利用ADCK2抗体分析肝癌组织中蛋白表达水平，发现其表达下调与线粒体能量代谢异常相关，提示ADCK2在肿瘤代谢重编程中的潜在作用。
3. **"ADCK2 interacts with CoQ biosynthesis proteins: Evidence from co-immunoprecipitation studies"**
*Authors: Johnson R, et al.*
**摘要**: 通过ADCK2抗体进行免疫共沉淀实验，揭示其与辅酶Q合成通路蛋白的相互作用，表明ADCK2可能通过调控辅酶Q生成影响线粒体呼吸链功能。
4. **"Altered ADCK2 expression in Parkinson’s disease patient-derived neurons"**
*Authors: Lee S, et al.*
**摘要**: 采用ADCK2抗体检测帕金森病患者神经元中的蛋白表达，发现其表达异常与线粒体功能障碍相关，为神经退行性疾病的机制研究提供新方向。
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**注**：以上文献为模拟示例，实际引用时需通过PubMed、Google Scholar等平台检索真实存在的文献。建议使用关键词“ADCK2 antibody”、“ADCK2 function”或结合具体研究领域(如癌症、代谢疾病)进行精准查询。
The ADCK2 (AarF domain-containing kinase 2) antibody is a tool used to detect and study the ADCK2 protein, which plays a role in cellular energy metabolism. ADCK2 is part of the ADCK/COQ8 protein family and is implicated in the biosynthesis of coenzyme Q10 (CoQ10), a critical component of the mitochondrial electron transport chain. This kinase-like protein is thought to stabilize the CoQ10 synthesis complex, though its exact enzymatic mechanism remains under investigation. Dysregulation of ADCK2 has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, making it a target for biomedical research.
The ADCK2 antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It is widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to analyze ADCK2 expression, localization, and interaction partners in various tissues or cell lines. Researchers often validate antibody specificity using knockout controls or siRNA-mediated protein knockdown. Commercial ADCK2 antibodies are available from multiple suppliers, with variations in clonality (monoclonal/polyoclonal), conjugation tags (e.g., HRP, FITC), and species reactivity. Proper validation is essential due to potential cross-reactivity with homologous family members like ADCK3 or ADCK4. Recent studies have utilized ADCK2 antibodies to explore its role in metabolic reprogramming in tumors and its potential as a therapeutic target.
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