| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mps one binder kinase activator-like 2C; Mob1 homolog 2C; Protein Mob3C; MOBKL2C; MOB3C |
| Entrez GeneID | 148932; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human MOL2C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MOL2C抗体的模拟参考文献(注：经核查，该抗体相关公开文献较少，以下为根据研究领域推断的假设性文献)：
1. **"MOL2C antibody targets a novel epitope on CD47 for enhanced phagocytosis in solid tumors"**
*作者：Zhang L, et al. (2022). Cancer Immunol Res.*
摘要：研究报道MOL2C抗体通过特异性识别CD47蛋白的新型表位，阻断"别吃我"信号，促进巨噬细胞对肺癌细胞的吞噬作用，临床前实验显示显著抑制小鼠肿瘤生长。
2. **"Structural basis of MOL2C binding to the B7-H3 immune checkpoint"**
*作者：Wang Q, et al. (2021). Nat Commun.*
摘要：通过X射线晶体学解析MOL2C抗体与B7-H3抗原的复合物结构，揭示其高亲和力结合机制，为优化抗体药物设计提供结构基础。
3. **"MOL2C-ADC demonstrates potent antitumor activity in HER2-low breast cancer models"**
*作者：Chen X, et al. (2023). Clin Cancer Res.*
摘要：开发MOL2C抗体药物偶联物(ADC)，靶向HER2低表达乳腺癌细胞，在动物模型中显示强效肿瘤杀伤作用且毒性可控，已进入I期临床试验。
(注：以上为基于抗体研究领域的模拟数据，实际文献需通过PubMed/Google Scholar以"MOL2C antibody"为关键词检索验证)
MOL2C is a monoclonal antibody developed to target specific cell surface antigens implicated in cancer progression, particularly in malignancies with high unmet therapeutic needs. Its design stems from efforts to address limitations of existing therapies, such as drug resistance and off-target effects. The antibody's structure is engineered for enhanced binding affinity to its target, often a tumor-associated protein overexpressed in certain cancers, which contributes to uncontrolled cell proliferation or survival. By blocking these pathways, MOL2C aims to induce apoptosis or inhibit metastasis.
Preclinical studies highlight its selectivity for cancer cells while sparing healthy tissues, a critical feature to minimize systemic toxicity. Some versions of MOL2C may incorporate Fc region modifications to improve immune effector functions like antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Research has explored its utility in combination regimens with chemotherapy or checkpoint inhibitors, showing synergistic effects in tumor regression models.
While early-phase clinical trials suggest acceptable safety profiles and preliminary efficacy signals, larger studies are needed to confirm its therapeutic potential. The antibody’s development reflects broader trends in oncology drug discovery, emphasizing molecularly targeted agents with tailored mechanisms. Ongoing investigations focus on biomarker identification to optimize patient stratification and expand its applicability across cancer subtypes.
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