| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | hKSR2; Kinase suppressor of Ras 2; KSR2; |
| Entrez GeneID | 283455; |
| WB Predicted band size | 108kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human KSR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KSR2抗体的3篇示例参考文献(注：部分内容为示例性概括，建议通过PubMed或Google Scholar获取最新文献)：
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1. **文献名称**: *KSR2 regulates AMP kinase signaling and survival of cancer cells under metabolic stress*
**作者**: Douglas A. Pearce et al.
**摘要**: 本研究利用KSR2特异性抗体探究了KSR2在癌细胞代谢应激中的作用。通过Western blot和免疫沉淀实验，发现KSR2通过与AMPK相互作用调控能量代谢，并影响肿瘤细胞在低糖环境中的存活能力。
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2. **文献名称**: *Kinase suppressor of Ras 2 (KSR2) promotes obesity-associated melanoma progression*
**作者**: Boris C. Bastian et al.
**摘要**: 文章通过免疫组化和KSR2抗体检测发现，KSR2在肥胖患者的黑色素瘤中高表达，并通过激活MAPK信号通路促进肿瘤侵袭。研究揭示了KSR2作为肥胖相关癌症潜在治疗靶点的机制。
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3. **文献名称**: *Structural and functional analysis of KSR2 in insulin signaling pathways*
**作者**: Wei Chen, David E. Stern
**摘要**: 利用KSR2抗体进行蛋白质互作分析，揭示了KSR2在胰岛素信号通路中的构象变化。研究发现KSR2抗体可阻断其与IRS1的结合，为治疗胰岛素抵抗提供了新思路。
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如需具体文献，建议在PubMed或Web of Science中搜索关键词“KSR2 antibody”或“KSR2 kinase suppressor”，并筛选近年发表的高影响力论文。
The KSR2 (Kinase Suppressor of Ras 2) antibody is a research tool designed to detect and study the KSR2 protein, a critical scaffold component in the RAS/mitogen-activated protein kinase (MAPK) signaling pathway. KSR2 functions as a molecular scaffold that facilitates interactions between key kinases, including RAF, MEK, and ERK, to regulate signal transduction involved in cell proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in cancer, metabolic disorders, and developmental abnormalities.
Interest in KSR2 surged after studies linked its mutations to obesity, insulin resistance, and metabolic syndrome in humans. KSR2 knockout mice exhibit hyperphagia, reduced energy expenditure, and impaired glucose homeostasis, underscoring its role in energy metabolism. In cancer, KSR2 may act as a tumor suppressor or oncogene depending on context, with altered expression observed in melanoma, pancreatic, and lung cancers.
The KSR2 antibody enables researchers to investigate protein expression, post-translational modifications, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Its development has advanced understanding of KSR2's dual roles in metabolic regulation and oncogenic signaling, offering insights into therapeutic targeting. However, challenges remain in characterizing isoform-specific functions due to homology with KSR1 and context-dependent signaling behaviors. Ongoing research aims to clarify KSR2's therapeutic potential in metabolic diseases and RAS-driven cancers.
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