Rabbit Polyclonal TM16G Antibody

The TM16G antibody targets the TMEM16G protein, a member of the transmembrane protein 16 (TMEM16) family, which is implicated in diverse cellular processes. TMEM16G, also known as Anoctamin 6 (ANO6), is a calcium-activated phospholipid scramblase and chloride channel regulator. It plays critical roles in lipid redistribution across cell membranes, facilitating processes like blood coagulation, apoptosis, and membrane repair. Dysregulation of TMEM16G is linked to pathologies such as Scott syndrome (a bleeding disorder), muscular dystrophy, and cancer metastasis. The TM16G antibody is a key tool for studying these mechanisms, enabling detection and localization of TMEM16G in tissues or cell lines via techniques like Western blotting, immunofluorescence, or immunohistochemistry. Its development often involves immunizing host animals with peptide antigens specific to conserved or functional domains of TMEM16G. Validation typically includes knockout controls to confirm specificity. Researchers use this antibody to explore TMEM16G's role in membrane dynamics, ion transport, and disease pathways, aiding therapeutic target discovery. Commercial variants may vary in clonality (monoclonal/polyclonal), conjugates, or species reactivity, requiring careful selection based on experimental needs.