关键信息
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基因名
KIRREL3
- 应用
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别名
KIRREL3; KIAA1867; NEPH2; UNQ5923/PRO4502/PRO19814Kin of IRRE-like protein 3; Kin of irregular chiasm-like protein 3; Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3]
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZU9
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表达区间
1-778aa
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氨基酸序列
MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
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分子量
111.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KIRREL3, or Kin of IRRE like protein 3, is a member of the KIRREL family, which plays significant roles in neuronal development and the formation of synapses. Recent studies have highlighted its involvement in various neurodevelopmental processes and its potential implications in neuropsychiatric disorders. Researchers have focused on KIRREL3's function in cell adhesion and interaction with other proteins, which are crucial for establishing and maintaining synaptic integrity. Given its importance in neural connectivity, KIRREL3 has emerged as a candidate for studying synaptic dysfunction associated with conditions like autism spectrum disorder (ASD) and schizophrenia. The production of recombinant KIRREL3 protein allows for detailed investigations into its structural and functional properties, facilitating insights into its mechanisms of action in neuronal networks. By employing techniques such as crystallography and biochemical assays, scientists aim to elucidate how KIRREL3 mediates cellular signaling and adhesion. Understanding the molecular dynamics of KIRREL3 could pave the way for new therapeutic strategies targeting synaptic impairments, ultimately addressing the gaps in our knowledge regarding its role in both normal brain function and neurodevelopmental diseases. Furthermore, the development of KIRREL3-specific antibodies and assays may provide tools for the study of its expression patterns in various brain regions and developmental stages, contributing to a comprehensive understanding of its biological significance.
