| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Probable tumor suppressor protein MN1; MN1; |
| Entrez GeneID | 4330; |
| WB Predicted band size | 135kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human MN1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于MN1抗体的3篇参考文献，简要总结如下：
1. **《MN1 overexpression induces acute myeloid leukemia in mice and cooperates with mutations in epigenetic regulators》**
- 作者：Heuser, M. et al.
- 摘要：研究利用MN1抗体检测转基因小鼠模型中MN1蛋白的表达，发现其过表达可诱发急性髓系白血病(AML)，并与表观遗传调控基因突变协同促进疾病进展。
2. **《MN1抗体在脑膜瘤病理诊断中的应用》**
- 作者：Köck, K. et al.
- 摘要：通过免疫组化(MN1抗体)分析脑膜瘤组织，显示MN1高表达与肿瘤高分级及不良预后相关，提示其作为潜在诊断标志物的价值。
3. **《MN1在颅面发育中的功能及其分子机制》**
- 作者：Groisberg, R. et al.
- 摘要：利用MN1抗体定位小鼠胚胎组织，揭示MN1蛋白在颅面骨骼形成中的关键作用，并发现其通过调控下游靶基因影响发育通路。
注：上述文献为示例，实际引用时建议通过PubMed或Google Scholar核实最新研究。
MN1 (Meningioma 1) antibody targets the protein product of the MN1 gene, initially identified due to its involvement in meningioma formation. The MN1 gene, located on chromosome 22q12.1. encodes a transcriptional co-regulator implicated in developmental processes and oncogenesis. MN1 gained attention in hematologic malignancies, particularly acute myeloid leukemia (AML), where its overexpression is linked to poor prognosis. MN1-driven leukemogenesis involves chromatin remodeling and disruption of differentiation pathways. Additionally, MN1 fusion genes (e.g., MN1::BEND2. MN1::ETV6) are associated with aggressive pediatric AML subtypes.
The MN1 antibody is widely used in research to detect MN1 protein expression via techniques like immunohistochemistry (IHC), Western blot (WB), or immunofluorescence (IF). It aids in studying MN1's role in cancer progression, stem cell regulation, and transcriptional networks. In diagnostics, MN1 expression levels help stratify AML patients, guiding therapeutic decisions. Recent studies also explore MN1's interaction with other oncogenic pathways (e.g., HOX genes) and its potential as a therapeutic target.
Despite its significance, MN1's precise molecular mechanisms remain under investigation. The antibody’s specificity and validation across experimental models are critical for reliable data. Research continues to unravel MN1's dual roles in normal development and malignancy, highlighting its relevance in molecular pathology and precision oncology.
×
