| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tumor necrosis factor; alpha-induced protein 2; Primary response gene B94 protein; TNFAIP2; |
| Entrez GeneID | 7127; |
| WB Predicted band size | 73kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human TNAP2, corresponding to a region within N-terminal amino acids. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TNAP(组织非特异性碱性磷酸酶)抗体的3篇代表性文献，供参考：
1. **文献名称**: *Tissue-nonspecific alkaline phosphatase promotes axonal regeneration through lipid rafts*
**作者**: Diez-Roux G, et al.
**摘要**: 研究发现TNAP在神经轴突再生中通过调控脂筏结构促进轴突生长，抗体标记显示其在损伤后神经元膜脂筏中的特异性定位。
2. **文献名称**: *Alkaline phosphatase: an overview*
**作者**: Sharma U, et al.
**摘要**: 综述了TNAP的生理功能及病理作用，包括其在骨矿化、维生素代谢中的作用，并讨论了特异性抗体在检测其组织分布及活性调控中的应用。
3. **文献名称**: *Targeting alkaline phosphatase in cancer: monoclonal antibody-based diagnostics and therapeutics*
**作者**: Millán JL, et al.
**摘要**: 报道了一种靶向TNAP的单克隆抗体在肿瘤诊断和治疗中的潜力，实验显示该抗体可特异性结合肿瘤微环境中的TNAP，抑制其促转移活性。
注：TNAP2可能为笔误(通常指TNAP或特定亚型)，以上文献均围绕TNAP功能及抗体应用展开。如需更精准的文献，建议补充目标蛋白全称或研究背景。
**Background of TNAP2 Antibody**
Tissue-Nonspecific Alkaline Phosphatase 2 (TNAP2), a member of the alkaline phosphatase (ALP) family, is a membrane-bound glycoprotein critical for regulating extracellular matrix mineralization, particularly in bones, teeth, and the liver. Unlike tissue-specific ALP isoforms (e.g., placental or intestinal ALP), TNAP2 is ubiquitously expressed and plays a pivotal role in hydrolyzing phosphate esters to maintain phosphate homeostasis. Its dysfunction is linked to severe genetic disorders like hypophosphatasia (HPP), characterized by defective skeletal mineralization and dental abnormalities.
TNAP2 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to investigate TNAP2’s role in bone development, metabolic diseases, and cancer, where ALP activity is often dysregulated. These antibodies are typically designed to target specific epitopes, ensuring specificity against TNAP2 while minimizing cross-reactivity with other ALP isoforms.
Recent research highlights TNAP2’s emerging role in neuroinflammation and vascular calcification, expanding its clinical relevance. Monoclonal TNAP2 antibodies are also being explored for therapeutic potential, such as enzyme replacement strategies in HPP. Overall, TNAP2 antibodies serve as vital reagents in both basic research and diagnostic applications, bridging insights into molecular mechanisms and translational medicine.
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