Rabbit Polyclonal 45205 Antibody

The 45205 antibody, commercially available through various suppliers like Cell Signaling Technology (CST), is a monoclonal antibody primarily targeting phosphorylated STAT3 (p-STAT3) at the Tyr705 residue. STAT3 (Signal Transducer and Activator of Transcription 3) is a transcription factor involved in regulating cell proliferation, survival, and differentiation. Phosphorylation at Tyr705 activates STAT3. enabling its dimerization, nuclear translocation, and DNA-binding activity. Dysregulated STAT3 signaling is implicated in cancer, inflammation, and autoimmune diseases, making it a key therapeutic target. The 45205 antibody is widely used in research to investigate STAT3 activation pathways, particularly in studies exploring oncogenesis, immune responses, and drug development. It is validated for applications such as Western blotting, immunoprecipitation, and immunohistochemistry (IHC), and is often utilized in both human and mouse model systems. Raised in rabbits, this antibody exhibits high specificity for the phosphorylated form of STAT3. helping researchers distinguish active versus inactive states of the protein. Its role in detecting aberrant STAT3 activation in tumors or inflammatory tissues has made it a valuable tool for mechanistic studies and biomarker analysis. Researchers frequently pair it with total STAT3 antibodies to assess activation levels in experimental and clinical samples.