| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Retinol-binding protein III; cellular; CRBP-III; HRBPiso; RBP5 |
| Entrez GeneID | 83758; |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human CRBP III. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CRBP III抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
1. **文献名称**：*"Characterization of Cellular Retinol-Binding Protein-III (CRBP-III) in Human Tissues"*
**作者**：Aström A. et al.
**摘要**：本研究通过免疫组织化学和Western blot技术，利用特异性CRBP III抗体分析了其在人类多种组织中的表达模式，发现CRBP III在脂肪组织和特定上皮细胞中高表达，提示其在脂质代谢和细胞分化中的潜在作用。
2. **文献名称**：*"Development of a Monoclonal Antibody Against CRBP-III for Retinoid Signaling Studies"*
**作者**：Kawaguchi R. et al.
**摘要**：报道了一种新型单克隆抗体的开发，该抗体能特异性识别CRBP III蛋白。通过体外实验验证了抗体在检测细胞视黄醇转运及信号通路中的应用，并证实CRBP III在调控维生素A代谢中的关键功能。
3. **文献名称**：*"CRBP-III Expression in Cancer: Insights from Immunohistochemical Analysis"*
**作者**：Li Y. et al.
**摘要**：利用CRBP III抗体对多种癌症样本进行检测，发现其表达水平与肿瘤分化程度及患者预后相关，尤其在乳腺癌中低表达可能与转移风险增加有关，为CRBP III的肿瘤生物学作用提供了新证据。
(注：上述文献为示例性内容，实际引用需根据具体论文调整。)
CRBP III (Cellular Retinol-Binding Protein III), also known as RBP5. is a member of the lipid-binding protein family that facilitates the transport and metabolism of retinol (vitamin A) within cells. It plays a critical role in regulating intracellular retinol homeostasis by binding and solubilizing hydrophobic retinol, ensuring its safe delivery to enzymes involved in retinoid metabolism, such as retinol dehydrogenases. CRBP III is primarily expressed in tissues with high metabolic activity, including the heart, skeletal muscle, and adipose tissue, distinguishing it from other CRBP isoforms (CRBP I and II) that are more abundant in the liver, eyes, or intestines.
Antibodies targeting CRBP III are essential tools for studying its expression, localization, and functional roles in physiological and pathological contexts. These antibodies enable researchers to investigate CRBP III's involvement in lipid metabolism, cellular differentiation, and energy homeostasis, particularly in obesity, diabetes, and cardiovascular diseases. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissue samples or cell cultures. Additionally, CRBP III antibodies contribute to exploring its interaction with retinoid signaling pathways, which influence gene regulation and cellular processes. The development and validation of specific, high-affinity CRBP III antibodies remain crucial for advancing research into vitamin A biology and its implications in metabolic disorders.
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