| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 3.5.-.-; dsRNA adenosine deaminase; RNA-editing deaminase 1; RNA-editing enzyme 1; |
| Entrez GeneID | 104; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ADARB1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ADARB1抗体相关的文献摘要(模拟生成，仅供参考)：
1. **"ADARB1 regulates axonal plasticity through RNA editing during neural development"**
- 作者：K. Yamashita et al.
- 摘要：研究利用ADARB1特异性抗体，通过免疫荧光和Western blot验证其在神经元轴突发育中的动态表达，发现ADARB1通过编辑关键mRNA调控突触可塑性。
2. **"Antibody validation for ADARB1 isoforms in human glioblastoma models"**
- 作者：M. Thompson & R. Silva
- 摘要：开发并验证了两种针对ADARB1不同剪接变体的单克隆抗体，证明其在胶质母细胞瘤组织中特异性识别ADARB1蛋白，并揭示其与肿瘤分级的关联性。
3. **"ADARB1-mediated RNA editing modulates cardiac function"**
- 作者：L. Chen et al.
- 摘要：通过ADARB1抗体进行免疫组化分析，发现ADARB1在小鼠心肌细胞中高表达，其缺失导致离子通道mRNA编辑异常，进而引发心律失常表型。
注：以上内容为示例性模拟，实际文献需通过PubMed或Google Scholar检索关键词"ADARB1 antibody"获取。
The ADARB1 antibody is a crucial tool for studying the ADARB1 protein, also known as adenosine deaminase acting on RNA B1 or ADAR2. ADARB1 belongs to the RNA-specific adenosine deaminase family, which catalyzes the conversion of adenosine to inosine (A-to-I editing) in double-stranded RNA. This post-transcriptional modification diversifies the transcriptome, influencing RNA splicing, stability, and protein coding. ADARB1 is predominantly expressed in the brain and plays a vital role in neuronal function, including neurotransmitter receptor editing (e.g., GluA2 subunit of AMPA receptors) and neurodevelopment. Dysregulation of ADARB1 is linked to neurological disorders (e.g., epilepsy, ALS, depression), cancer, and autoimmune conditions.
ADARB1 antibodies enable researchers to detect, quantify, and localize the protein in tissues or cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. They are essential for investigating ADARB1’s expression patterns, regulatory mechanisms, and disease associations. For instance, reduced ADARB1 levels have been observed in glioblastoma and epilepsy models, while its overexpression is implicated in autoimmune responses. These antibodies also support drug discovery by evaluating therapeutic interventions targeting RNA editing pathways. Validation of ADARB1 antibodies ensures specificity, often through knockout controls or siRNA knockdown, to avoid cross-reactivity with related proteins like ADAR1 or ADAR3. Overall, ADARB1 antibodies are indispensable for advancing research in neurobiology, oncology, and RNA epigenetics.
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