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Rabbit Polyclonal IPKA Antibody

  • 中文名: IPKA抗体
  • 别    名: IPKA; OKRBCI; PKI-alpha; PRKACN1; cAMP-dependent protein kinase inhibitor alpha
货号: IPDX41976
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/100-1/500 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesIPKA; OKRBCI; PKI-alpha; PRKACN1; cAMP-dependent protein kinase inhibitor alpha
Entrez GeneID5569;
WB Predicted band size8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human IPKA.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及IPKA(cAMP依赖性蛋白激酶A,PKA)抗体的代表性文献摘要示例(注:文献信息为模拟,具体文献需根据实际数据库检索确认):

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1. **文献名称**:*"Antibody-based detection of protein kinase A activity in Alzheimer's disease models"*

**作者**:Smith J, et al.

**摘要**:该研究利用特异性抗PKA催化亚基的抗体,分析了阿尔茨海默病小鼠脑中PKA活性变化,发现磷酸化tau蛋白的积累与PKA活性异常升高相关,提示其可能通过异常信号通路加剧神经退行性病变。

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2. **文献名称**:*"Role of PKA in cardiac β-adrenergic signaling: Insights from phospho-specific antibodies"*

**作者**:Lee H, et al.

**摘要**:通过开发针对PKA磷酸化底物的抗体,揭示了PKA在心脏β-肾上腺素受体激活后对离子通道蛋白(如RyR2)的调控机制,为心力衰竭中PKA信号失调提供了分子证据。

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3. **文献名称**:*"Differential expression of PKA regulatory subunits in cancer: Implications for therapeutic targeting"*

**作者**:Wang Y, et al.

**摘要**:采用亚基特异性PKA抗体(如抗RIα/RIIβ),分析了多种癌症组织中PKA亚基的分布差异,发现RIα过表达与化疗耐药性显著相关,提示其作为潜在治疗靶点的价值。

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如需具体文献,建议通过PubMed或Web of Science以关键词“PKA antibody application”、“PKA subunit-specific antibody”等检索近年研究。

背景信息

IPKA antibodies, also known as anti-Inositol Polyphosphate Multikinase (IPMK) antibodies, target IPMK, a conserved enzyme involved in diverse cellular processes. IPMK catalyzes the phosphorylation of inositol phosphates, critical secondary messengers regulating calcium signaling, gene expression, and metabolic pathways. Initially identified in yeast, IPMK homologs exist in mammals, where they exhibit both kinase-independent scaffolding functions and enzymatic activity.

IPMK interacts with key signaling hubs like mTORC1 and AMPK, influencing nutrient sensing, autophagy, and cell growth. Its role in cancer has drawn significant interest, as IPMK overexpression correlates with tumor proliferation and metastasis. Additionally, IPMK regulates neuronal development and synaptic plasticity, implicating it in neurodegenerative disorders.

IPKA antibodies are essential tools for studying IPMK localization, expression, and molecular interactions. They enable techniques such as Western blotting, immunohistochemistry, and immunoprecipitation, aiding research into IPMK's dual roles in metabolism and disease. Recent studies explore IPMK as a therapeutic target, with IPKA antibodies facilitating drug development by monitoring IPMK inhibition in preclinical models. Despite progress, the pleiotropic nature of IPMK necessitates further research to fully unravel its pathophysiological mechanisms.

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