| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CKS-1; CKS1B; cyclin-dependent kinases regulatory subunit 1; |
| Entrez GeneID | 1163; |
| WB Predicted band size | 9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from N-terminal of human CKS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CKS1抗体的3篇文献摘要示例(注：文献为示例性内容，实际引用需核实具体数据库)：
1. **文献名称**: "CKS1 overexpression promotes tumor progression and predicts poor prognosis in colorectal cancer"
**作者**: Li Y, et al.
**摘要**: 本研究通过免疫组化(使用CKS1抗体)分析结直肠癌组织中CKS1蛋白表达水平，发现其高表达与肿瘤分期、转移及患者生存率降低显著相关，提示CKS1可作为潜在预后标志物。
2. **文献名称**: "CKS1 interacts with CDC25A to regulate cell cycle progression in human cancer cells"
**作者**: Wang H, et al.
**摘要**: 利用CKS1抗体进行免疫共沉淀实验，揭示了CKS1与CDC25A的相互作用机制，证实其通过调控G1/S期转换促进癌细胞增殖，为靶向干预提供理论依据。
3. **文献名称**: "Development of a novel monoclonal CKS1 antibody for detecting aggressive breast cancer subtypes"
**作者**: Zhang Q, et al.
**摘要**: 研究团队开发了一种高特异性CKS1单克隆抗体，验证其在乳腺癌组织中的检测效能，发现CKS1在三阴性乳腺癌中显著高表达，与化疗耐药性相关。
(注：以上内容为示例，实际文献需通过PubMed/Google Scholar等平台以“CKS1 antibody”或“CKS1 biomarker”等关键词检索。)
The CKS1 antibody targets the CKS1 protein (Cyclin-Dependent Kinase Regulatory Subunit 1), a key component in cell cycle regulation. CKS1 belongs to the CKS/Suc1 family of proteins, which interact with cyclin-dependent kinases (CDKs) to modulate their activity and stability. It plays a critical role in transitioning cells through the G1/S phase and exiting mitosis by facilitating CDK-mediated phosphorylation events. CKS1 is also involved in the ubiquitin-proteasome degradation pathway, particularly in the Skp2-p27 axis, where it promotes the degradation of p27. a cyclin-dependent kinase inhibitor, thereby driving cell proliferation.
Research highlights CKS1's overexpression in various cancers, including breast, colorectal, and lung cancers, where it correlates with poor prognosis, metastasis, and therapeutic resistance. This makes CKS1 a potential biomarker for cancer progression and a target for therapeutic intervention. Antibodies against CKS1 are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, localization, and interactions in both normal and pathological conditions. Additionally, CKS1 antibodies aid in exploring its role in DNA damage response, checkpoint control, and oncogenic signaling pathways, providing insights into mechanisms underlying tumorigenesis and opportunities for drug development.
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