| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor SOX-8/9/17/18; SOX8/9/17/18; |
| Entrez GeneID | 30812; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from C-terminal of human SOX8/9/17/18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **SOX8/9/17/18抗体** 的参考文献示例(注：内容为示例性概括，非真实文献)：
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1. **文献名称**: *SOX8 regulates testis development in mice via transcriptional activation of Fgf9*
**作者**: Barrionuevo F, et al.
**摘要**: 研究使用兔抗SOX8多克隆抗体，通过免疫组化(IHC)和染色质免疫沉淀(ChIP)验证其在睾丸支持细胞中的表达，揭示SOX8通过调控Fgf9参与性别决定。
2. **文献名称**: *SOX9 ablation disrupts chondrogenesis via dysregulation of ECM components*
**作者**: Bi W, et al.
**摘要**: 通过小鼠单克隆SOX9抗体进行免疫荧光和Western blot，证明SOX9缺失导致软骨发育异常，并影响胶原蛋白II和聚集蛋白的表达。
3. **文献名称**: *SOX17 directs endodermal differentiation in human embryonic stem cells*
**作者**: Sinner D, et al.
**摘要**: 利用山羊多克隆SOX17抗体进行流式细胞术和免疫染色，证实SOX17在内胚层分化中的关键作用，并调控下游靶基因FoxA2的表达。
4. **文献名称**: *SOX18 drives lymphatic endothelial cell specification in zebrafish*
**作者**: Cermenati S, et al.
**摘要**: 采用抗SOX18抗体进行原位杂交和免疫组化，揭示SOX18在斑马鱼淋巴管内皮细胞发育中的必要性，并与Prox1存在协同调控。
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**说明**：以上文献示例聚焦于抗体在特定研究中的应用(如免疫组化、Western blot等)，并简要概括了基因功能。实际引用时需核实文献真实性及具体实验细节。
SOX8. SOX9. SOX17. and SOX18 belong to the SOX (Sry-related HMG-box) family of transcription factors, which regulate diverse developmental processes by binding DNA through a conserved high-mobility group (HMG) domain. These proteins play critical roles in cell fate determination, differentiation, and tissue homeostasis. SOX8 and SOX9 (subgroup E) are involved in sex determination, neural crest development, and chondrogenesis. SOX9 is essential for male gonad development and cartilage formation, while SOX8 exhibits overlapping functions with SOX9 in certain contexts, such as maintaining progenitor cells in the nervous system. SOX17 and SOX18 (subgroup F) are implicated in endodermal lineage specification, vascular/lymphatic development, and organogenesis. SOX17 regulates endoderm-derived organ formation (e.g., gut, liver) and pluripotency in stem cells, whereas SOX18 is crucial for lymphatic vessel formation and cardiovascular development.
Antibodies targeting these SOX proteins are vital tools for studying their expression, localization, and functional roles in development and disease. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map protein distribution in tissues or assess expression levels in pathological conditions, such as cancer. For instance, SOX9 overexpression is linked to tumor progression in multiple cancers, while SOX17/18 dysregulation is associated with vascular anomalies or metastasis. Validation of antibody specificity is critical due to high homology among SOX family members, requiring careful controls (e.g., knockout validation) to avoid cross-reactivity. These antibodies continue to advance research in developmental biology, regenerative medicine, and oncology.
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