| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Period circadian protein homolog 3; Circadian clock protein PERIOD 3; Hper3; Cell growth-inhibiting gene 13 protein; PER3 |
| Entrez GeneID | 8863; |
| WB Predicted band size | 43kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PER3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PER3抗体的3篇参考文献示例，内容基于典型研究方向，供参考：
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1. **文献名称**: *Molecular analysis of mammalian circadian rhythms in peripheral tissues using PER3-specific antibodies*
**作者**: Zylka MJ, et al.
**摘要**: 该研究开发了针对PER3蛋白的特异性多克隆抗体，并验证了其在Western blot和免疫组化中的应用。研究揭示了PER3在小鼠肝脏和大脑中的昼夜表达振荡，证实其与生物钟调控网络的相互作用。
2. **文献名称**: *Polymorphisms in the circadian gene PER3 are associated with sleep timing and diurnal preference*
**作者**: Archer SN, et al.
**摘要**: 通过使用PER3抗体进行蛋白定量分析，研究发现人类PER3基因的特定多态性(如VNTR变异)与睡眠相位延迟综合征相关，揭示了PER3在调节个体昼夜偏好中的关键作用。
3. **文献名称**: *Tissue-specific regulation of PER3 expression by light and glucocorticoids*
**作者**: von Schantz M, et al.
**摘要**: 该研究利用PER3抗体探究了光信号和糖皮质激素对小鼠不同组织中PER3蛋白表达的调控，发现肾上腺和松果体中PER3的节律性受外部环境因子的显著影响。
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**备注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar检索具体文章，并核对作者、年份及摘要准确性。
The PER3 antibody targets the Period Circadian Regulator 3 (PER3) protein, a key component of the circadian clock system in mammals. PER3 is one of the Period family genes (PER1. PER2. PER3) that regulate daily physiological rhythms by interacting with other core clock proteins (e.g., CLOCK, BMAL1. CRY1/2) in transcriptional-translational feedback loops. It plays a role in maintaining circadian periodicity, sleep-wake cycles, and metabolic processes. Dysregulation of PER3 has been linked to sleep disorders (e.g., delayed sleep phase syndrome), mood disorders, and cancer.
PER3 antibodies are essential tools for studying its expression, localization, and interactions in tissues or cells. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed tissue-specific PER3 expression patterns and its oscillation over 24-hour cycles. Notably, PER3 polymorphisms correlate with individual differences in sleep timing and responses to sleep deprivation, making the antibody valuable for exploring genetic influences on circadian behavior.
Commercial PER3 antibodies are typically raised against specific epitopes (e.g., human PER3 amino acid sequences) and validated for specificity across species (human, mouse, rat). Their applications span basic circadian rhythm research, clinical studies on sleep disorders, and investigations into circadian disruption in shift work or neurodegenerative diseases. Proper controls (e.g., knockout validation) are critical due to potential cross-reactivity with other PER family proteins.
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