| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C21orf1; PBF; PTTG; PTTG-binding factor; pituitary tumor-transforming gene 1 protein-interacting protein |
| Entrez GeneID | 754; |
| WB Predicted band size | 20kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from C-terminal of human PTTG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PTTG抗体的3篇示例参考文献(内容为虚构，仅供格式参考)：
1. **文献名称**：*PTTG1 as a Prognostic Biomarker in Colorectal Cancer: Immunohistochemical Analysis*
**作者**：Zhang L, et al.
**摘要**：通过免疫组化检测PTTG1蛋白在结直肠癌组织中的表达，发现其高表达与肿瘤转移及患者生存期缩短显著相关，提示PTTG抗体可作为预后评估工具。
2. **文献名称**：*Mechanistic Role of PTTG in Hepatocellular Carcinoma Cell Invasion*
**作者**：Wang Y, et al.
**摘要**：研究利用PTTG抗体沉默肝癌细胞中的PTTG表达，证实其通过调控MMP-9通路促进肿瘤侵袭，为靶向治疗提供依据。
3. **文献名称**：*Correlation Between Serum PTTG Autoantibodies and Pituitary Adenoma Recurrence*
**作者**：Smith J, et al.
**摘要**：通过ELISA检测垂体腺瘤患者血清中PTTG自身抗体水平，发现抗体阳性与肿瘤复发风险升高相关，可能用于术后监测。
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注：以上文献为示例，实际引用需查询PubMed、Google Scholar等数据库获取真实研究。
**Background of PTTG Antibodies**
Pituitary tumor-transforming gene (PTTG), also known as securin, is a regulatory protein encoded by the *PTTG1* gene. Initially identified in pituitary tumor cells, PTTG plays a critical role in cell cycle progression by controlling sister chromatid separation during mitosis. Dysregulation of PTTG expression disrupts genomic stability, contributing to tumorigenesis, metastasis, and angiogenesis. Overexpression of PTTG is observed in various cancers, including pituitary adenomas, breast, colorectal, and lung cancers, correlating with aggressive phenotypes and poor prognosis.
PTTG antibodies are immunological tools designed to detect and quantify PTTG protein levels in research and clinical settings. These antibodies enable the study of PTTG's functional roles in cancer biology, such as its interaction with cell cycle checkpoints, DNA repair mechanisms, and oncogenic signaling pathways. In diagnostics, PTTG antibodies are utilized in immunohistochemistry (IHC) or immunoassays to assess tumor progression and therapeutic responses. Their specificity and sensitivity make them valuable for identifying PTTG as a potential biomarker for early cancer detection or targeted therapy.
Additionally, PTTG antibodies aid in exploring its non-mitotic roles, including transcriptional regulation and promotion of angiogenesis via VEGF activation. Despite their utility, challenges remain in optimizing antibody specificity across different tissue types and minimizing cross-reactivity. Ongoing research focuses on refining these tools to enhance their clinical applicability in personalized oncology.
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