| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMS1; AdoMet synthetase; EC 2.5.1.6; MAT-I/III; MATA1 |
| Entrez GeneID | 4331; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human MAT1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与MAT1抗体相关的文献摘要示例(文献信息为虚构示例，仅用于格式参考，实际文献需通过学术数据库检索)：
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1. **文献名称**: *MAT1 modulates CDK7 activity in transcriptional regulation and cell cycle progression*
**作者**: Tassan JP, et al.
**摘要**: 研究揭示了MAT1作为CDK7激酶复合物的关键组分，通过稳定CDK7与cyclin H的相互作用调控RNA聚合酶II的C端结构域磷酸化，影响转录起始及细胞周期G1/S期转换。
2. **文献名称**: *Structural insights into the MAT1-CDK7-cyclin H complex in TFIIH assembly*
**作者**: Yankulov K, Bentley DL.
**摘要**: 通过晶体结构分析，阐明MAT1在TFIIH复合物中桥接CDK7-cyclin H与ERCC3/XPB解旋酶的结构基础，为MAT1抗体在癌症中异常表达的功能研究提供依据。
3. **文献名称**: *MAT1 antibody-based profiling identifies its prognostic role in hepatocellular carcinoma*
**作者**: Roy R, et al.
**摘要**: 利用MAT1特异性抗体进行免疫组化分析，发现MAT1在肝癌组织中高表达且与患者生存率负相关，提示其作为潜在治疗靶点的价值。
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**注意**：以上文献信息为示例，实际引用请通过PubMed、Google Scholar等平台检索关键词“MAT1 antibody”、“CDK7-MAT1 complex”或“CAK complex”，并核实PMID等真实信息。
MAT1 (Menage à Trois 1), also known as MNAT1. is a critical regulatory protein that functions as a component of the CDK-activating kinase (CAK) complex. This complex, composed of MAT1. cyclin H, and CDK7. plays dual roles in cell cycle regulation and transcriptional processes. As part of CAK, MAT1 stabilizes the interaction between CDK7 and cyclin H, enabling CDK7 to phosphorylate key cell cycle kinases (CDKs 1. 2. 4. 6) to drive cell cycle progression. Additionally, the CAK complex associates with the transcription factor IIH (TFIIH) to facilitate RNA polymerase II-mediated transcription initiation.
MAT1 antibodies are widely used in research to study its expression, localization, and interactions in cellular pathways. Dysregulation of MAT1 has been implicated in cancers, including breast and ovarian cancers, where its overexpression correlates with tumor proliferation and poor prognosis. These antibodies aid in detecting MAT1 levels in clinical samples, elucidating its role in oncogenesis and therapeutic resistance.
Studies also explore MAT1's potential as a therapeutic target, particularly in combination with CDK7 inhibitors. Its involvement in both cell cycle control and transcription makes it a focal point for understanding diseases linked to proliferative or transcriptional abnormalities. MAT1 antibodies thus serve as essential tools for dissecting molecular mechanisms and developing targeted cancer therapies.
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