| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mesenchyme homeobox 2; |
| Entrez GeneID | 4223; |
| WB Predicted band size | 33kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human MEOX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MEOX2抗体的3篇参考文献示例：
1. **文献名称**：*"MEOX2 regulates vascular smooth muscle cell differentiation via modulation of key transcription factors"*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化及Western blot使用MEOX2抗体，发现MEOX2在血管平滑肌细胞分化中通过调控Myocardin和SRF的表达发挥作用，为血管发育异常相关疾病提供了机制解释。
2. **文献名称**：*"MEOX2 as a prognostic biomarker in hepatocellular carcinoma: An immunohistochemical study"*
**作者**：Chen L, et al.
**摘要**：利用MEOX2抗体对肝癌组织样本进行染色，发现MEOX2高表达与患者预后不良显著相关，提示其可能通过促进肿瘤细胞侵袭和转移参与肝癌进展。
3. **文献名称**：*"MEOX2 deficiency accelerates cellular senescence through p53 pathway activation"*
**作者**：Wang Y, et al.
**摘要**：通过敲低MEOX2并结合抗体检测，研究揭示了MEOX2缺失通过激活p53通路诱导细胞衰老，为衰老相关退行性疾病提供了潜在治疗靶点。
(注：以上文献为示例，实际引用时需以真实发表的论文为准。)
The MEOX2 (Mesenchyme Homeobox 2) antibody targets the MEOX2 protein, a transcription factor encoded by the *MEOX2* gene, which belongs to the homeobox gene family. MEOX2. also known as MOX2. plays critical roles in embryonic development, particularly in mesoderm-derived tissues. It regulates cell differentiation, proliferation, and tissue patterning, with significant involvement in skeletal myogenesis, vascular development, and angiogenesis. Structurally, MEOX2 contains a homeodomain that facilitates DNA binding, enabling transcriptional regulation of downstream genes.
Research links MEOX2 to pathological conditions, including cancer (e.g., tumor metastasis, epithelial-mesenchymal transition), atherosclerosis, and neurodegenerative diseases like Alzheimer’s. The antibody is widely used in studies to detect MEOX2 expression via techniques like Western blot, immunohistochemistry, and immunofluorescence. It is typically generated in hosts (e.g., rabbits, mice) using immunogenic peptides or recombinant protein fragments. Specificity is validated through knockdown experiments or competitive assays. Commercial MEOX2 antibodies aid in exploring its biological functions, tissue-specific expression, and mechanisms in disease models, providing insights for therapeutic targeting.
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