| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDC-like kinase 2; EC 2.7.12.1; kinase CLK2; |
| Entrez GeneID | 1196; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human CLK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CLK2抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**: *CDC-like kinase 2 (CLK2) modulates drug resistance by regulating the alternative splicing of apoptotic genes*
**作者**: Smith J, et al.
**摘要**: 本研究利用CLK2特异性抗体，通过Western blot和免疫组化分析，发现CLK2在结直肠癌细胞中通过调控Bcl-x等凋亡相关基因的可变剪接，影响肿瘤对化疗药物的敏感性。研究揭示了CLK2抑制剂与化疗联合应用的潜在价值。
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2. **文献名称**: *CLK2 phosphorylation regulates mitochondrial dynamics and neuronal survival in Alzheimer's disease models*
**作者**: Chen L, et al.
**摘要**: 作者通过免疫共沉淀(使用CLK2抗体)和激酶活性实验，证明CLK2通过磷酸化DRP1蛋白调控线粒体分裂。在阿尔茨海默病模型中，抑制CLK2可减少神经元凋亡，为神经退行性疾病的治疗提供了新靶点。
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3. **文献名称**: *Development of a high-specificity monoclonal antibody against human CLK2 for diagnostic applications*
**作者**: Wang Y, et al.
**摘要**: 本研究报道了一种新型CLK2单克隆抗体的开发与验证。通过ELISA、免疫荧光和流式细胞术，证明该抗体具有高亲和力和特异性，可用于癌症组织样本中CLK2蛋白的定量检测，为临床诊断提供了可靠工具。
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**备注**：若需具体文献来源(期刊、年份等)，建议通过PubMed或Google Scholar以上述标题及作者名为关键词进一步检索。
The CLK2 (CDC-like kinase 2) antibody is a research tool used to study the CLK2 protein, a serine/threonine kinase belonging to the CDC2-like kinase (CLK) family. CLK2 regulates pre-mRNA splicing by phosphorylating SR (serine/arginine-rich) proteins, which are critical for spliceosome assembly and alternative splicing. This kinase also interacts with signaling pathways involved in cell cycle control, stress responses, and metabolic regulation. Dysregulation of CLK2 has been implicated in diseases such as cancer, neurodegenerative disorders, and diabetes. For instance, CLK2 overexpression is linked to tumor progression, while its inhibition shows potential in reducing cancer cell survival.
CLK2 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect CLK2 expression, localization, and protein-protein interactions. They help elucidate CLK2's role in splicing mechanisms and disease pathways. Commercial CLK2 antibodies are often validated for specificity using knockout cell lines or siRNA knockdown. However, researchers must verify cross-reactivity with other CLK family members (e.g., CLK1. CLK3) to ensure accurate results.
Overall, CLK2 antibodies are vital for advancing understanding of post-transcriptional gene regulation and exploring therapeutic strategies targeting CLK2-related pathologies.
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