Rabbit Polyclonal TF2H1 Antibody

The TFIIH (Transcription Factor II Human) antibody targets components of the TFIIH complex, a critical multi-subunit protein assembly involved in transcription initiation and DNA repair. The TFIIH complex, composed of ten subunits (e.g., XPB, XPD, p62. p44), plays dual roles: it facilitates RNA polymerase II-mediated transcription by unwinding DNA at promoter regions and participates in nucleotide excision repair (NER) by recognizing and repairing DNA lesions such as UV-induced thymine dimers. Mutations in TFIIH subunits (e.g., XPB, XPD) are linked to genetic disorders like xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD), characterized by photosensitivity, neurological defects, or premature aging. Antibodies against TFIIH subunits, such as anti-XPD or anti-p62. are widely used in research to study transcription mechanisms, DNA repair pathways, and disease pathogenesis. They enable techniques like immunoprecipitation, Western blotting, and immunofluorescence to assess TFIIH localization, expression, and interactions. Additionally, these antibodies aid in diagnosing TFIIH-related disorders by detecting protein abnormalities in patient cells. Recent studies also explore TFIIH's role in cancer, as dysregulated DNA repair contributes to genomic instability and chemoresistance. Overall, TFIIH antibodies are essential tools for dissecting the complex interplay between transcription, DNA repair, and human disease.