| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myeloid zinc finger 1; MZF-1; Zinc finger protein 42; Zinc finger and SCAN domain-containing protein 6; MZF1 |
| Entrez GeneID | 7593; |
| WB Predicted band size | 82kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from N-terminal of human MZF-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及MZF-1抗体的参考文献摘要，供参考：
1. **文献名称**：*MZF-1 regulates the expression of a novel oncogene, MZF-1 antisense RNA, in human myeloid cells*
**作者**：Hromas, R., et al.
**摘要**：该研究利用MZF-1特异性抗体通过染色质免疫沉淀(ChIP)和Western blot技术，验证了MZF-1蛋白在髓系细胞中与其自身反义RNA的调控关系，揭示了其在白血病发生中的潜在作用。
2. **文献名称**：*The role of MZF-1 in the tumorigenesis of prostate cancer*
**作者**：Gaboli, M., et al.
**摘要**：通过免疫组化(IHC)和免疫荧光技术，研究发现MZF-1抗体检测到在前列腺癌组织中异常高表达的MZF-1蛋白，并证实其通过调控细胞周期相关基因促进肿瘤增殖。
3. **文献名称**：*Myeloid zinc finger 1 (MZF-1) interacts with NF-κB to regulate inflammatory responses*
**作者**：Wang, Y., et al.
**摘要**：研究使用MZF-1抗体在小鼠巨噬细胞中进行了Co-IP实验，发现MZF-1与NF-κB形成复合物，共同调控炎症因子的表达，为抗炎治疗提供新靶点。
4. **文献名称**：*MZF-1 as a potential biomarker for DNA damage response*
**作者**：Sakamoto, K., et al.
**摘要**：通过Western blot和流式细胞术，该文献证实MZF-1抗体检测的蛋白水平在DNA损伤后显著升高，提示其在细胞应激反应中的功能。
**注**：以上文献信息为示例性概括，实际引用时需核对具体期刊名称、年份及原文内容。如需真实文献，建议通过PubMed或Google Scholar以“MZF-1 antibody”为关键词检索。
**Background of MZF-1 Antibody**
The Myeloid Zinc Finger 1 (MZF-1) antibody is a tool used to detect and study the MZF-1 protein, a transcription factor belonging to the zinc finger protein family. MZF-1. encoded by the *ZNF42* gene, contains two distinct zinc finger domains: an N-terminal domain involved in transcriptional repression and a C-terminal domain mediating DNA binding. It plays critical roles in hematopoiesis, cell differentiation, and oncogenesis. MZF-1 regulates target genes associated with cell proliferation, apoptosis, and migration, making it significant in both normal development and disease contexts, such as leukemia and solid tumors.
The MZF-1 antibody is widely utilized in research to investigate its expression patterns, subcellular localization, and interaction partners. Studies highlight its dual role in cancer—acting as a tumor suppressor or promoter depending on cellular context—and its involvement in stem cell maintenance. Researchers employ this antibody in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to explore MZF-1's regulatory mechanisms. Its development and validation have advanced understanding of MZF-1's contributions to transcriptional networks and disease pathways, offering potential insights for therapeutic targeting in malignancies and hematopoietic disorders.
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