| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inositol 1; 4; 5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; InsP 3-kinase B |
| Entrez GeneID | 3707; |
| WB Predicted band size | 102kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from Internal of human ITPKB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ITPKB抗体的3篇参考文献示例(注：以下为假设性描述，实际文献需通过数据库核实)：
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1. **文献名称**：*ITPKB modulates T cell receptor signaling through calcium regulation*
**作者**：Pouillon, Y., et al.
**摘要**：研究揭示了ITPKB通过催化IP3生成IP4调控T细胞受体介导的钙信号，其抗体被用于验证其在T细胞激活中的功能缺失效应，证明ITPKB缺陷导致过度免疫反应。
2. **文献名称**：*ITPKB overexpression in B-cell malignancies detected by monoclonal antibodies*
**作者**：Koss, H., et al.
**摘要**：利用特异性抗体检测ITPKB在B细胞淋巴瘤中的表达，发现其高表达与患者不良预后相关，提示ITPKB可能成为治疗靶点。
3. **文献名称**：*Autoantibodies against ITPKB in systemic lupus erythematosus*
**作者**：Zhu, Y., et al.
**摘要**：首次报道系统性红斑狼疮患者血清中存在抗ITPKB自身抗体，并通过抗体检测揭示其与疾病活动度的相关性，为自身免疫机制提供新见解。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“ITPKB antibody”或“ITPKB autoantibody”获取最新研究。
**Background of ITPKB Antibody**
ITPKB (Inositol-trisphosphate 3-kinase B) is an enzyme that phosphorylates inositol 1.4.5-trisphosphate (IP3) to generate inositol 1.3.4.5-tetrakisphosphate (IP4), regulating intracellular calcium signaling and influencing cellular processes like proliferation, apoptosis, and immune responses. ITPKB is particularly critical in immune cells, including T and B lymphocytes, where it modulates calcium-dependent signaling pathways essential for activation and function. Dysregulation of ITPKB has been implicated in autoimmune diseases, cancer, and neurological disorders.
Antibodies targeting ITPKB are vital tools for studying its expression, localization, and role in disease mechanisms. They are used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to quantify protein levels or visualize tissue-specific distribution. For example, ITPKB antibodies have helped identify its overexpression in certain cancers (e.g., leukemia) or its reduced activity in autoimmune conditions like lupus. Additionally, these antibodies support research into therapeutic strategies, such as small-molecule inhibitors targeting ITPKB signaling pathways.
Recent studies also highlight ITPKB's potential as a biomarker or therapeutic target, driving demand for validated antibodies to advance translational research. Ensuring antibody specificity remains a challenge due to structural similarities among kinase family members, underscoring the need for rigorous validation in diverse experimental models.
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