| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK- alpha |
| Entrez GeneID | 1606; |
| WB Predicted band size | 80kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human DGKA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于DGKA(二酰甘油激酶α)抗体的参考文献示例(注：以下为模拟示例，实际文献需通过学术数据库核实)：
---
1. **文献名称**：*"Role of Diacylglycerol Kinase α in T Cell Signaling and Immune Response"*
**作者**：Sanjabi S, et al.
**摘要**：通过Western blot和免疫荧光技术，使用特异性DGKA抗体研究其在T细胞激活中的作用，发现DGKA通过调控二酰甘油代谢影响T细胞受体信号传导。
2. **文献名称**：*"Overexpression of DGKA in Breast Cancer: Clinical Implications and Mechanistic Insights"*
**作者**：Murakami T, et al.
**摘要**：利用DGKA抗体进行免疫组化分析，发现乳腺癌组织中DGKA表达显著升高，且与肿瘤侵袭性和患者预后不良相关，提示其作为潜在治疗靶点。
3. **文献名称**：*"Development of a Monoclonal Antibody Against DGKA for Enzyme Activity Profiling"*
**作者**：Gomez-Cambronero J, et al.
**摘要**：报道了一种高特异性DGKA单克隆抗体的开发，验证其在ELISA和流式细胞术中的应用，用于定量检测细胞中DGKA的酶活性变化。
4. **文献名称**：*"Altered DGKA Expression in Neurodegenerative Disease Models"*
**作者**：Smith RL, et al.
**摘要**：通过免疫印迹和免疫组织化学技术，使用DGKA抗体分析阿尔茨海默病小鼠模型，发现脑组织中DGKA表达上调，提示其参与神经炎症通路。
---
建议通过PubMed、Google Scholar等平台以关键词“DGKA antibody”“diacylglycerol kinase alpha”检索最新文献以获取准确信息。
DGKA (diacylglycerol kinase alpha) is a key enzyme in lipid signaling, catalyzing the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). This reaction regulates the balance between DAG-mediated signaling (e.g., protein kinase C activation) and PA-mediated pathways, influencing cell proliferation, apoptosis, and immune responses. DGKA is particularly notable in immune cells, where it modulates T-cell receptor signaling and cytokine production. Dysregulation of DGKA has been linked to cancer, inflammatory diseases, and neurological disorders.
DGKA antibodies are essential tools for studying its expression, localization, and function. They enable detection via Western blotting, immunohistochemistry, and flow cytometry, aiding research in cellular signaling mechanisms and disease pathology. Recent studies explore DGKA's role in cancer progression, particularly its impact on metastasis and drug resistance, making it a potential therapeutic target. Antibodies against DGKA also support clinical investigations, such as correlating DGKA levels with patient outcomes or evaluating pharmacological inhibitors. However, challenges remain in ensuring antibody specificity due to homology among DGK isoforms. Validated DGKA antibodies are critical for advancing both basic research and translational applications in oncology and immunology.
×
