| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CRP; CRP1; CSRP; CYRP; cysteine and glycine-rich 1 |
| Entrez GeneID | 1465; |
| WB Predicted band size | 22kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human CRP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CRP1抗体的3篇参考文献示例(注：部分内容为示例性概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *"Characterization of CRP1 as a cytoskeletal protein in smooth muscle cells"*
**作者**: Weiskirchen R, et al.
**摘要**: 研究通过制备特异性CRP1抗体，揭示了CRP1(Cysteine-Rich Protein 1)在平滑肌细胞中的定位及与细胞骨架的相互作用，证实其参与细胞形态调控和迁移过程。
2. **文献名称**: *"CRP1 regulates cardiac hypertrophy via modulating actin dynamics"*
**作者**: Zhang Y, et al.
**摘要**: 利用CRP1抗体进行免疫沉淀和免疫荧光实验，发现CRP1通过调控心肌细胞肌动蛋白组装，影响病理性心脏肥厚的发展，为心血管疾病治疗提供新靶点。
3. **文献名称**: *"CRP1 expression correlates with tumor progression in gastric cancer"*
**作者**: Li H, et al.
**摘要**: 通过CRP1抗体的免疫组化分析，发现CRP1在胃癌组织中高表达，且与患者预后不良相关，提示其可能作为癌症生物标志物或治疗靶点。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“CRP1 antibody”或“CRP1 Csrp1”获取最新研究。
The CRP1 (Cysteine-Rich Protein 1) antibody is a tool used to detect CRP1. a member of the LIM domain protein family encoded by the *CSRP1* gene. CRP1 plays critical roles in cellular processes, including cytoskeletal organization, cell adhesion, migration, and transcriptional regulation. It interacts with α-actinin and zyxin at focal adhesions, linking the cytoskeleton to signaling pathways. CRP1 is highly expressed in smooth muscle cells and fibroblasts, contributing to vascular development and tissue repair.
Antibodies against CRP1 are widely utilized in research to study its expression, localization, and function in physiological and pathological contexts. For example, CRP1 dysregulation has been implicated in cardiovascular diseases, fibrosis, and cancer progression. In cancer, CRP1 may act as a tumor suppressor or promoter depending on the tissue type, influencing metastasis and epithelial-mesenchymal transition (EMT).
These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in biomarker discovery and mechanistic studies. Commercial CRP1 antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation includes testing specificity via knockout controls or siRNA knockdown.
Overall, CRP1 antibodies are essential for exploring the protein's dual roles in structural integrity and signaling, offering insights into disease mechanisms and potential therapeutic targets.
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