| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2 adrenergic receptor subtype C4; ADRA2C |
| Entrez GeneID | 152; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human Adrenergic Receptor α-2C. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Adrenergic Receptor α-2C(ADRA2C)抗体的示例参考文献(内容为模拟示例，建议通过学术数据库核实具体文献)：
1. **"Adrenergic Receptor Subtypes: Localization and Functional Roles"**
- **作者**: Bylund, D.B. et al.
- **摘要**: 综述α-2肾上腺素受体亚型(包括α-2C)的组织分布、信号通路及生理作用，强调抗体在受体亚型定位和功能研究中的应用。
2. **"α2C-Adrenoceptor Expression in Hypertensive Rat Models"**
- **作者**: Hein, L. et al.
- **摘要**: 通过抗α-2C受体抗体检测高血压动物模型中心血管组织的受体表达变化，发现其表达上调可能与交感神经活性异常相关。
3. **"Development of a Specific Antibody for α2C-Adrenergic Receptor Detection"**
- **作者**: Rorabaugh, B.R. et al.
- **摘要**: 报道一种高特异性ADRA2C抗体的开发及验证，证明其在免疫印迹和免疫组化中有效识别人类和小鼠组织中的α-2C受体。
4. **"Role of α2C-Adrenoceptors in Anxiety-like Behavior: Antibody-based Localization Studies"**
- **作者**: Link, R.E. et al.
- **摘要**: 结合基因敲除模型和抗体标记技术，揭示α-2C受体在中枢神经系统特定脑区的表达与焦虑行为的调控关系。
(注：上述文献名称及内容为示例，实际文献需通过PubMed、Google Scholar等平台检索确认。)
**Background of Adrenergic Receptor α-2C (ADRA2C) Antibody**
Adrenergic receptors (ARs) are G protein-coupled receptors (GPCRs) that mediate physiological responses to catecholamines like epinephrine and norepinephrine. The α-2 adrenergic receptor family (α-2A, α-2B, α-2C) regulates inhibitory functions, primarily by coupling to Gαi/o proteins to suppress adenylate cyclase activity, reducing intracellular cAMP levels. Among these, the α-2C subtype (ADRA2C) is less widely expressed but plays critical roles in the central and peripheral nervous systems. It is implicated in modulating neurotransmitter release, sympathetic nervous activity, and cardiovascular function.
ADRA2C antibodies are tools designed to detect and study the expression, localization, and function of this receptor. These antibodies are essential in research applications such as Western blotting, immunohistochemistry, and flow cytometry, enabling the investigation of ADRA2C in tissues like the brain, smooth muscle, and adrenal glands. Dysregulation of ADRA2C has been linked to conditions such as hypertension, heart failure, and neuropsychiatric disorders (e.g., depression, schizophrenia), making its study clinically relevant.
The development of specific ADRA2C antibodies has advanced understanding of receptor signaling pathways, trafficking, and interactions with ligands or drugs. Such research supports the exploration of therapeutic agents targeting α-2C receptors for cardiovascular or neurological diseases. Validation of these antibodies ensures specificity, often through knockout controls or competitive assays, to avoid cross-reactivity with other α-2 subtypes. Overall, ADRA2C antibodies remain vital for elucidating the receptor’s physiological and pathological roles.
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