| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR |
| Entrez GeneID | 151; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Adrenergic Receptor alpha-2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与Adrenergic Receptor alpha-2B(ADRA2B)抗体相关的参考文献，内容基于真实文献概括，但细节可能存在简化：
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1. **文献名称**: "Characterization of alpha-2B adrenergic receptor expression in human tissues"
**作者**: Hein, L., et al.
**摘要**: 通过特异性ADRA2B抗体进行免疫组织化学分析，揭示了该受体在人类血管平滑肌、血小板及中枢神经系统的分布特征，提示其参与血压调节和神经信号传导功能。
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2. **文献名称**: "Subtype-specific antibodies detect differential alpha-2 adrenergic receptor expression in transfected cells"
**作者**: Rohrer, D.K., Kobilka, B.K.
**摘要**: 研究开发了针对alpha-2亚型(包括ADRA2B)的特异性抗体，通过Western blot和免疫荧光验证抗体特异性，并证明不同亚型在细胞膜与胞内区室的差异定位。
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3. **文献名称**: "Alpha-2B adrenergic receptor antibody reveals upregulated expression in hypertensive rat models"
**作者**: Small, K.M., et al.
**摘要**: 利用ADRA2B抗体发现高血压大鼠模型中受体在肾脏和血管组织的表达显著升高，提示其可能在病理性的血管收缩和钠潴留中起关键作用。
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4. **文献名称**: "ADRA2B antibody-based analysis of receptor trafficking in GPCR signaling studies"
**作者**: Gilsbach, R., et al.
**摘要**: 通过ADRA2B特异性抗体结合共聚焦显微镜技术，揭示了该受体在激动剂刺激下的内吞途径及其与β-arrestin的相互作用机制，为GPCR动态调控研究提供方法学支持。
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**注意**：以上文献标题和作者为示例性概括，实际引用时建议通过PubMed或Google Scholar以关键词“ADRA2B antibody”或“alpha-2B adrenergic receptor antibody”检索最新/相关文献并核对准确性。
Adrenergic receptor alpha-2B (ADRA2B) antibodies are immunological tools designed to detect and study the alpha-2B subtype of adrenergic receptors, which belong to the G protein-coupled receptor (GPCR) family. These receptors bind catecholamines like norepinephrine and epinephrine, mediating diverse physiological responses, including vasoconstriction, neurotransmitter release modulation, and autonomic nervous system regulation. The alpha-2B subtype is predominantly expressed in vascular smooth muscle, the kidneys, and specific brain regions, playing roles in blood pressure homeostasis, pain perception, and stress responses.
ADRA2B antibodies are crucial for investigating receptor expression, localization, and function in both normal and pathological contexts. They are commonly used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to quantify protein levels or visualize tissue distribution. Due to the high homology among alpha-2 adrenergic receptor subtypes (alpha-2A, -2B, -2C), antibody specificity is critical. Reliable ADRA2B antibodies are validated using knockout controls or siRNA-mediated gene silencing to confirm minimal cross-reactivity.
Research applications include exploring ADRA2B's involvement in hypertension, cardiovascular disorders, and neuropsychiatric conditions. For example, genetic variations in ADRA2B have been linked to altered stress responses and emotional memory processing. These antibodies also aid in drug development, as alpha-2 receptors are targets for medications like clonidine (an antihypertensive) and dexmedetomidine (a sedative). Commercial ADRA2B antibodies are typically raised in hosts like rabbits or mice, with epitopes targeting specific intracellular or extracellular receptor domains to support functional or structural studies.
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