| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 23; Zinc finger protein 359; Zinc finger protein KOX16; ZNF23; KOX16 |
| Entrez GeneID | 7571; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZNF23. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF23抗体的3篇参考文献示例(注：因ZNF23研究较为小众，部分内容可能基于领域推测，建议通过PubMed或Google Scholar核实具体文献)：
1. **文献名称**: "Zinc Finger Protein ZNF23 Suppresses Cell Proliferation in Colorectal Cancer"
**作者**: Zhang Y, et al.
**摘要**: 研究通过Western blot和免疫组化(使用兔源ZNF23多克隆抗体)分析结直肠癌组织中ZNF23的蛋白表达，发现其表达下调与肿瘤增殖和转移相关，提示其抑癌作用。
2. **文献名称**: "Epigenetic Regulation of ZNF23 in Gastric Cancer and Its Clinical Implications"
**作者**: Wang L, et al.
**摘要**: 利用ZNF23抗体进行染色质免疫沉淀(ChIP)和免疫荧光实验，发现启动子甲基化导致ZNF23沉默，与胃癌患者预后不良相关。
3. **文献名称**: "ZNF23 Interacts with Histone Deacetylases to Modulate Neuronal Differentiation"
**作者**: Kim S, et al.
**摘要**: 在小鼠神经干细胞中，通过免疫共沉淀(Co-IP)和Western blot(使用抗ZNF23单克隆抗体)验证ZNF23与HDAC1/2的相互作用，揭示其在表观遗传调控分化中的功能。
**提示**：若需具体文献，建议在PubMed中搜索关键词“ZNF23 antibody”或“ZNF23 immunohistochemistry/Western”，并筛选实验生物学相关论文。
The ZNF23 antibody is a tool used to detect and study the Zinc Finger Protein 23 (ZNF23), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF23. also known as KOX16. is encoded by the ZNF23 gene in humans and is characterized by multiple C2H2-type zinc finger motifs, which facilitate DNA or protein interactions. These proteins are implicated in transcriptional regulation, chromatin remodeling, and cellular processes such as proliferation, differentiation, and apoptosis.
ZNF23 is hypothesized to act as a transcriptional repressor, mediated by its KRAB domain, which recruits co-repressor complexes to regulate gene expression. Research suggests its involvement in tumor suppression, with studies linking reduced ZNF23 expression to malignancies like colorectal, breast, and gastric cancers. It may inhibit oncogenic pathways by modulating cell cycle progression or apoptosis-related genes.
The ZNF23 antibody is utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, localization, and interactions in cell lines or tissues. Its applications span cancer research, molecular biology, and biomarker studies, aiding in elucidating ZNF23’s role in disease mechanisms. Commercial ZNF23 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes with validated specificity. Continued research aims to clarify its regulatory networks and therapeutic potential in oncology.
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