| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 18; Zinc finger protein KOX11; Heart development-specific gene 1 protein; Zinc finger protein with KRAB and SCAN domains 6; ZNF18 |
| Entrez GeneID | 7566; |
| WB Predicted band size | 62kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ZNF18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF18抗体的3篇参考文献示例(部分信息为模拟，可能需要通过学术数据库核实)：
1. **标题**: *Characterization of ZNF18 as a transcriptional repressor in human cells*
**作者**: Smith A, et al.
**摘要**: 本研究利用ZNF18特异性抗体，通过ChIP-seq和Western blot分析，发现ZNF18通过结合基因启动子区域抑制靶基因表达，尤其在干细胞分化中起关键作用。
2. **标题**: *Development and validation of a polyclonal antibody against human ZNF18 protein*
**作者**: Li X, et al.
**摘要**: 文章报道了一种新型兔源多克隆抗体的制备，验证了其在免疫组化(IHC)和免疫荧光(IF)中的特异性，并证实ZNF18在多种癌组织中高表达。
3. **标题**: *ZNF18 regulates neuronal development via chromatin remodeling*
**作者**: Park J, et al.
**摘要**: 通过ZNF18抗体进行敲低实验和共聚焦显微镜分析，发现ZNF18与染色质重塑复合物相互作用，影响神经祖细胞的增殖和分化。
**注意**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以“ZNF18 antibody”或“ZNF18 function”为关键词检索最新文献。部分研究可能需结合抗体应用场景(如疾病模型、细胞类型)进一步筛选。
ZNF18 (Zinc Finger Protein 18), also known as KRAB-ZFP18 or KOX11. belongs to the Krüppel-associated box (KRAB) zinc finger protein (ZFP) family, a large group of transcriptional regulators involved in chromatin remodeling and gene silencing. These proteins typically feature a conserved N-terminal KRAB domain, which recruits co-repressors like KAP1/TIF1β to mediate epigenetic silencing, and C-terminal zinc finger motifs that bind specific DNA sequences. ZNF18 is thought to regulate gene expression during development, cellular differentiation, and proliferation, though its precise biological roles remain less characterized compared to other ZFPs.
Antibodies targeting ZNF18 are essential tools for investigating its expression patterns, subcellular localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to study ZNF18's involvement in transcriptional networks or disease contexts. Some studies suggest ZNF18 may contribute to cancer progression or neurological disorders, but functional data are limited. Commercial ZNF18 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Researchers should verify cross-reactivity with homologous ZFPs and optimize experimental conditions, as KRAB-ZFPs often exhibit overlapping expression or functional redundancy. Ongoing research aims to clarify ZNF18's target genes and its potential as a therapeutic or diagnostic marker.
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