| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein lyl-1; Lymphoblastic leukemia-derived sequence 1; LYL1; |
| Entrez GeneID | 4066; |
| WB Predicted band size | 29kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human Lyl-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Lyl-1抗体的3篇参考文献示例(注：文献信息为模拟虚构，仅作格式参考)：
1. **"Lyl-1 regulates the maintenance and self-renewal of leukemia stem cells"**
- **作者**: Meng, X. et al.
- **摘要**: 本研究利用Lyl-1特异性抗体，通过流式细胞术和免疫沉淀技术，揭示了Lyl-1在急性髓系白血病(AML)干细胞中的关键作用。实验表明，抑制Lyl-1表达可显著降低白血病细胞的增殖能力。
2. **"Lyl-1 interacts with Notch signaling to drive T-cell acute lymphoblastic leukemia"**
- **作者**: Capron, C. et al.
- **摘要**: 通过免疫印迹和免疫组化技术，作者使用Lyl-1抗体证明其在T-ALL患者样本中高表达，并与Notch信号通路协同促进肿瘤发生。阻断Lyl-1可抑制小鼠模型中的肿瘤生长。
3. **"Developmental role of Lyl-1 in hematopoietic lineage commitment"**
- **作者**: Zhu, H. et al.
- **摘要**: 研究利用Lyl-1抗体在斑马鱼模型中分析其表达模式，发现Lyl-1在早期造血祖细胞分化中起关键作用，敲除Lyl-1会导致红系和髓系细胞发育异常。
(注：实际文献需通过PubMed/Google Scholar等平台检索确认。)
The Lyl-1 antibody targets the Lyl-1 protein, a basic helix-loop-helix (bHLH) transcription factor first identified in the early 1990s during studies of T-cell acute lymphoblastic leukemia (T-ALL). Lyl-1 belongs to the TAL-1/SCL family of hematopoietic regulators and is encoded by the *LYL1* gene located on human chromosome 19p13. It plays a role in hematopoiesis, particularly in the development and maintenance of early hematopoietic progenitors and lymphoid lineages. Dysregulation of Lyl-1 has been linked to leukemogenesis, as its aberrant expression disrupts normal differentiation and promotes uncontrolled proliferation of immature T-cells.
The Lyl-1 antibody is widely used in research to detect Lyl-1 protein expression in cellular and tissue samples via techniques like Western blotting, immunohistochemistry, and flow cytometry. It helps elucidate Lyl-1’s functional roles in both normal and malignant hematopoiesis. Studies suggest Lyl-1 may act as an oncogenic driver in subsets of leukemia, making it a potential biomarker or therapeutic target. However, its precise mechanisms remain under investigation, including interactions with other transcriptional regulators and signaling pathways.
This antibody is critical for advancing understanding of Lyl-1’s dual role in development and disease, bridging molecular biology with clinical oncology. Its applications extend to modeling hematopoietic disorders and screening targeted therapies in preclinical settings.
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