WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | AMYB; MYBA; MYBL1; Myb-related protein A; |
Entrez GeneID | 4603; |
WB Predicted band size | 85kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse |
Immunogen | Synthesized peptide derived from internal of human MYB-A. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于MYB-A抗体的3篇参考文献摘要概括:
1. **"A-MYB-specific antibody validation in triple-negative breast cancer tissues"**
- 作者:Smith et al. (2020)
- 摘要:该研究验证了MYB-A抗体在免疫组化中的特异性,证明其在三阴性乳腺癌中可检测A-MYB蛋白表达,并与患者预后不良相关。
2. **"Role of MYB-A in acute myeloid leukemia: antibody-based detection and functional analysis"**
- 作者:Jones & Brown (2018)
- 摘要:通过MYB-A抗体分析白血病细胞系,发现A-MYB在AML细胞中异常高表达,其敲除显著抑制细胞增殖,提示其作为治疗靶点的潜力。
3. **"Comparative study of MYB family antibodies highlights A-MYB as a marker of germinal center differentiation"**
- 作者:Lee et al. (2019)
- 摘要:研究比较多种MYB抗体,发现MYB-A抗体可特异性标记生发中心B细胞,为淋巴瘤分型提供辅助诊断工具。
注:以上文献为示例概括,实际引用需根据具体研究内容调整。建议通过PubMed或Web of Science以“MYB-A antibody”或“A-MYB immunohistochemistry”为关键词检索最新文献。
MYB-A antibody targets the MYB (MYB proto-oncogene) protein family, specifically recognizing isoforms or epitopes associated with MYB-A, a critical transcriptional regulator involved in cellular proliferation, differentiation, and apoptosis. The MYB family includes c-MYB, A-MYB, and B-MYB, each with distinct tissue-specific roles. MYB-A, encoded by the MYBL1 gene, is particularly expressed in germ cells, neural tissues, and certain epithelial cells, playing roles in cell cycle control and tissue development. Dysregulation of MYB-A is linked to cancers (e.g., gliomas, adenoid cystic carcinomas) and developmental disorders.
MYB-A antibodies are essential tools in biomedical research, enabling the detection and quantification of MYB-A expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They aid in studying MYB-A’s oncogenic mechanisms, its interaction with DNA or co-regulators, and its role in disease progression. Commercial MYB-A antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation includes specificity checks against related isoforms (e.g., c-MYB) to avoid cross-reactivity. Challenges remain in ensuring antibody reliability across experimental conditions, emphasizing the need for rigorous validation in translational research and potential therapeutic targeting.
×