| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 682; ZNF682; |
| Entrez GeneID | 91120; |
| WB Predicted band size | 58kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZNF682. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF682抗体的3篇参考文献的示例(注：以下内容为模拟生成，实际文献可能需要通过学术数据库核实)：
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1. **文献名称**: "ZNF682 as a Novel Prognostic Marker in Hepatocellular Carcinoma: Insights from Immunohistochemical Analysis"
**作者**: Wang, L. et al.
**摘要**: 本研究通过自主研发的兔源多克隆ZNF682抗体，在肝细胞癌组织中进行免疫组化检测，发现ZNF682高表达与患者生存期缩短显著相关，提示其可能作为肝癌预后的生物标志物。
2. **文献名称**: "Development and Validation of a Monoclonal Antibody Specific for Human ZNF682"
**作者**: Kim, S. et al.
**摘要**: 报道了一种新型小鼠单克隆ZNF682抗体的开发，经Western blot和免疫荧光验证其特异性，成功应用于研究ZNF682在细胞核内的定位及其与DNA损伤修复通路的关联。
3. **文献名称**: "ZNF682 Regulates Epithelial-Mesenchymal Transition in Colorectal Cancer via Antibody-Based Functional Screening"
**作者**: Chen, X. et al.
**摘要**: 利用商业化ZNF682抗体(货号AB123.ABC公司)进行功能筛选，发现ZNF682通过调控Snail蛋白影响结直肠癌细胞的转移，为靶向治疗提供潜在靶点。
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如需获取真实文献，建议在 **PubMed** 或 **Web of Science** 中检索关键词“ZNF682 antibody”或“ZNF682 immunohistochemistry”，并筛选近5年的实验性研究或抗体开发类论文。
**Background of ZNF682 Antibody**
The ZNF682 antibody is a tool used to detect ZNF682 (Zinc Finger Protein 682), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZFP) family. These proteins are characterized by tandem C2H2-type zinc finger domains, which facilitate sequence-specific DNA binding, and a KRAB domain, often involved in transcriptional repression. ZNF682 is implicated in regulating gene expression, particularly in processes like cell differentiation, proliferation, and apoptosis. Dysregulation of ZNF682 has been studied in cancer, where it may act as a tumor suppressor or oncogene depending on the context. For instance, reduced ZNF682 expression has been linked to poor prognosis in hepatocellular carcinoma, while its overexpression in other cancers suggests a role in promoting metastasis.
The ZNF682 antibody is widely utilized in research to investigate its expression patterns, subcellular localization (primarily nuclear), and interactions with chromatin or other proteins. It is validated for techniques such as Western blotting, immunofluorescence, and immunohistochemistry. Reliable antibodies are critical for elucidating ZNF682's functional mechanisms, including its involvement in epigenetic regulation and DNA damage responses. Ongoing studies aim to clarify its tissue-specific roles and potential as a therapeutic target or biomarker in diseases like cancer.
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