| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DAP-1; DLGAP1; DLGP1; Disks large-associated protein 1; Guanylate kinase-associated protein |
| Entrez GeneID | 9229; |
| WB Predicted band size | 108kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human DLGP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DLGAP1(DLG Associated Protein 1)抗体的示例文献(注：DLGP1可能是拼写误差，实际研究中多为DLGAP1相关研究。以下内容为模拟示例，实际引用需核实)：
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1. **文献名称**: *DLGAP1 regulates synaptic plasticity and cognitive function in autism spectrum disorders*
**作者**: Smith A, et al.
**摘要**: 研究通过Western blot和免疫组化技术，在小鼠模型中验证DLGAP1抗体的特异性，发现DLGAP1蛋白在突触后密度异常表达与自闭症行为表型相关，提示其参与突触可塑性调控。
2. **文献名称**: *Altered DLGAP1 expression in schizophrenia: A post-mortem brain study*
**作者**: Chen L, et al.
**摘要**: 使用DLGAP1抗体分析精神分裂症患者前额叶皮层样本，发现蛋白表达显著降低，并与谷氨酸受体信号通路异常关联，支持DLGAP1在精神疾病中的病理作用。
3. **文献名称**: *Antibody validation for DLGAP1 in knockout models reveals synaptic localization*
**作者**: Tanaka K, et al.
**摘要**: 通过基因敲除小鼠模型验证DLGAP1抗体的特异性，证明其在海马神经元中的突触定位，并应用于探究发育过程中DLGAP1的动态表达模式。
4. **文献名称**: *DLGAP1 as a potential biomarker in Alzheimer's disease*
**作者**: Wang Y, et al.
**摘要**: 利用DLGAP1抗体检测阿尔茨海默病患者脑脊液样本，发现其蛋白水平与tau病理严重程度呈负相关，提示其作为神经退行性疾病生物标志物的潜力。
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**注意**：以上文献为示例，实际研究中可能存在差异。建议通过PubMed或Google Scholar以“DLGAP1 antibody”或“DLGAP1 function”为关键词检索最新文献，并核对抗体货号(如Abcam、Cell Signaling等厂商)对应的引用文献。
DLGAP1 (Discs Large Homolog-Associated Protein 1), also known as SAPAP1. is a scaffolding protein primarily expressed in the postsynaptic density (PSD) of neuronal synapses. It interacts with members of the membrane-associated guanylate kinase (MAGUK) family, such as PSD-95. to organize synaptic proteins and regulate signal transduction. DLGAP1 plays a critical role in maintaining synaptic plasticity, which underpins learning and memory processes. Research links DLGAP1 dysfunction to neuropsychiatric disorders, including schizophrenia, autism spectrum disorders, and obsessive-compulsive disorder (OCD), with genetic studies identifying DLGAP1 variations as risk factors.
Antibodies targeting DLGAP1 are essential tools in neuroscience research, enabling the study of its expression, localization, and interactions in neuronal tissues. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to map synaptic protein networks. Commercial DLGAP1 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences specific to its conserved domains. Validation includes testing in knockout models or siRNA-treated cells to confirm specificity.
Recent studies also explore DLGAP1's role beyond the brain, such as in cancer progression, though its primary research focus remains synaptic biology. Reliable DLGAP1 antibodies are crucial for advancing understanding of synaptic pathology and developing targeted therapeutic strategies.
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