| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tripartite motif-containing protein 38; RING finger protein 15; Zinc finger protein RoRet; TRIM38; RNF15 |
| Entrez GeneID | 10475; |
| WB Predicted band size | 53kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human TRIM38. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及TRIM38抗体的研究文献摘要(注：文献信息为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：TRIM38 negatively regulates TLR3/4-mediated innate immune response by targeting TRIF for degradation
**作者**：Wang et al.
**摘要**：该研究利用TRIM38特异性抗体进行免疫共沉淀实验，发现TRIM38通过泛素化修饰促进衔接蛋白TRIF的降解，从而抑制TLR3/4信号通路介导的I型干扰素产生，揭示了TRIM38在先天免疫中的负调控作用。
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2. **文献名称**：TRIM38 modulates type I interferon signaling through USP18-STAT1 axis
**作者**：Zhang et al.
**摘要**：通过Western blot和免疫荧光(使用TRIM38抗体)发现，TRIM38通过增强USP18对STAT1的去ISG化修饰，抑制干扰素信号通路的过度激活，为病毒感染中免疫稳态维持提供机制解释。
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3. **文献名称**：TRIM38 restricts HIV-1 infection by targeting viral capsid for ubiquitination
**作者**：Li et al.
**摘要**：研究通过RNA干扰和TRIM38抗体介导的蛋白检测，证明TRIM38可直接结合HIV-1衣壳蛋白并介导其K48-linked泛素化降解，提出TRIM38作为宿主限制因子对抗逆转录病毒的新机制。
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提示：实际文献需通过PubMed/Google Scholar以"TRIM38 antibody"或"TRIM38 function"为关键词检索，并关注其抗体应用场景(如WB、IP等)。
TRIM38 is a member of the tripartite motif (TRIM) protein family, characterized by RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase and is involved in regulating innate immune responses, inflammatory signaling, and cellular homeostasis. TRIM38 modulates pathways like NF-κB and type I interferon by targeting signaling components such as TNF receptor-associated factors (TRAFs) and IκB kinase (IKK) complexes. It also plays roles in post-translational modifications, including ubiquitination and SUMOylation, influencing protein stability and activity.
Antibodies against TRIM38 are essential tools for studying its expression, localization, and molecular interactions. They are commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TRIM38's role in immune regulation, viral defense, and diseases such as autoimmune disorders or cancer. Researchers utilize these antibodies to validate TRIM38 knockout models, assess tissue-specific expression, or explore its dual regulatory effects—for instance, suppressing TLR-triggered inflammation while promoting RIG-I-mediated antiviral responses.
Recent studies highlight TRIM38's context-dependent functions, underscoring the importance of specific, high-quality antibodies to dissect its mechanisms. Commercial TRIM38 antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation often includes testing in knockout cell lines to confirm specificity, ensuring reliable detection in both physiological and pathological contexts.
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