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Rabbit Polyclonal TM16J Antibody

  • 中文名： TM16J抗体
  • 别    名： Transmembrane protein 16J; Tumor protein p53-inducible protein 5; p53-induced gene 5 protein; TMEM16J; PIG5
货号: IPDX41855
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/100-1/500 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTransmembrane protein 16J; Tumor protein p53-inducible protein 5; p53-induced gene 5 protein; TMEM16J; PIG5
Entrez GeneID338440;
WB Predicted band size90kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human TM16J.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TMEM16J(或相关TMEM16家族成员)抗体的参考文献摘要，按用户要求整理：

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1. **文献名称**：*TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression*

**作者**：Duvvuri U. et al.

**摘要**：该研究证实TMEM16A(ANO1)在头颈鳞状细胞癌中高表达，并促进肿瘤生长。研究中通过开发特异性TMEM16A抗体，验证了其在组织样本中的表达水平，并揭示其通过MAPK信号通路促进癌症进展的机制。

2. **文献名称**：*TMEM16B confers calcium-activated chloride currents critical for olfactory signal transduction*

**作者**：Yang Y.D. et al.

**摘要**：本文利用特异性TMEM16B(ANO2)抗体进行免疫组化分析，发现其在嗅球神经元中的高表达，证实其作为钙激活氯离子通道在嗅觉信号传递中的关键作用，抗体应用助力了蛋白定位与功能关联研究。

3. **文献名称**：*Expression cloning of TMEM16A as a calcium-activated chloride channel subunit*

**作者**：Schroeder B.C. et al.

**摘要**：研究团队通过表达克隆技术鉴定TMEM16A为钙激活氯离子通道的核心亚基，并开发了针对其特定表位的抗体，用于蛋白表达验证及组织分布分析，为后续功能研究提供工具支持。

4. **文献名称**：*Characterization of monoclonal antibodies targeting the extracellular domain of ANO1/TMEM16A*

**作者**：Jin X. et al.

**摘要**：该文献报道了针对ANO1胞外结构域的单克隆抗体制备与验证，通过流式细胞术和免疫荧光证实抗体特异性，并应用于癌症细胞表面ANO1的检测，为靶向治疗研究奠定基础。

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**注**：TM16J可能为TMEM16家族成员的笔误，上述文献聚焦于TMEM16A(ANO1)、TMEM16B(ANO2)等，均为该家族中研究较深入且抗体开发较成熟的成员。若需特定TMEM16J研究，建议进一步核实基因命名。

背景信息

The TM16J antibody is designed to target the TMEM16J protein, a member of the transmembrane protein 16 (TMEM16) family, which comprises calcium-activated chloride channels and phospholipid scramblases. TMEM16J, also known as anoctamin 9 (ANO9), is one of the less-characterized members of this family. While TMEM16A (ANO1) and TMEM16F (ANO6) are well-studied for their roles in ion transport and lipid scrambling, respectively, TMEM16J’s precise biological functions remain under investigation. Emerging evidence suggests its potential involvement in cellular processes such as membrane dynamics, ion homeostasis, or organelle regulation. The TM16J antibody is primarily used in research to detect and localize the protein in tissues or cultured cells, aiding in studies of its expression patterns and physiological roles. It is often employed in techniques like Western blotting, immunohistochemistry, or immunofluorescence. Dysregulation of TMEM16 family members has been linked to diseases, including cancer, neurological disorders, and cystic fibrosis, but TMEM16J’s specific pathological relevance remains unclear. Current research focuses on elucidating its interactions with other cellular components and its potential as a biomarker or therapeutic target. The antibody’s development supports ongoing efforts to map the functional diversity within the TMEM16 family.

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